A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor
Continuously monitoring transcutaneous CO<sub>2</sub> partial pressure is of crucial importance in the diagnosis and treatment of respiratory and cardiac diseases. Despite significant progress in the development of CO<sub>2</sub> sensors, their implementation as portable or w...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/5/333 |
| _version_ | 1797501188928700416 |
|---|---|
| author | Juan Pedro Cascales Xiaolei Li Emmanuel Roussakis Conor L. Evans |
| author_facet | Juan Pedro Cascales Xiaolei Li Emmanuel Roussakis Conor L. Evans |
| author_sort | Juan Pedro Cascales |
| collection | DOAJ |
| description | Continuously monitoring transcutaneous CO<sub>2</sub> partial pressure is of crucial importance in the diagnosis and treatment of respiratory and cardiac diseases. Despite significant progress in the development of CO<sub>2</sub> sensors, their implementation as portable or wearable devices for real-time monitoring remains under-explored. Here, we report on the creation of a wearable prototype device for transcutaneous CO<sub>2</sub> monitoring based on quantifying the fluorescence of a highly breathable CO<sub>2</sub>-sensing film. The developed materials are based on a fluorescent pH indicator (8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt or HPTS) embedded into hydrophobic polymer matrices. The film’s fluorescence is highly sensitive to changes in CO<sub>2</sub> partial pressure in the physiological range, as well as photostable and insensitive to humidity. The device and medical-grade films are based on our prior work on transcutaneous oxygen-sensing technology, which has been extensively validated clinically. |
| first_indexed | 2024-03-10T03:14:47Z |
| format | Article |
| id | doaj.art-9c30c22d9a3c4ce7b1478c3336412449 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T03:14:47Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9c30c22d9a3c4ce7b1478c33364124492023-11-23T10:16:00ZengMDPI AGBiosensors2079-63742022-05-0112533310.3390/bios12050333A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> SensorJuan Pedro Cascales0Xiaolei Li1Emmanuel Roussakis2Conor L. Evans3Wellman Center for Photomedicine, Massachusetts Genetal Hospital, Harvard Medical School, Charlestown, MA 02129, USAWellman Center for Photomedicine, Massachusetts Genetal Hospital, Harvard Medical School, Charlestown, MA 02129, USAWellman Center for Photomedicine, Massachusetts Genetal Hospital, Harvard Medical School, Charlestown, MA 02129, USAWellman Center for Photomedicine, Massachusetts Genetal Hospital, Harvard Medical School, Charlestown, MA 02129, USAContinuously monitoring transcutaneous CO<sub>2</sub> partial pressure is of crucial importance in the diagnosis and treatment of respiratory and cardiac diseases. Despite significant progress in the development of CO<sub>2</sub> sensors, their implementation as portable or wearable devices for real-time monitoring remains under-explored. Here, we report on the creation of a wearable prototype device for transcutaneous CO<sub>2</sub> monitoring based on quantifying the fluorescence of a highly breathable CO<sub>2</sub>-sensing film. The developed materials are based on a fluorescent pH indicator (8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt or HPTS) embedded into hydrophobic polymer matrices. The film’s fluorescence is highly sensitive to changes in CO<sub>2</sub> partial pressure in the physiological range, as well as photostable and insensitive to humidity. The device and medical-grade films are based on our prior work on transcutaneous oxygen-sensing technology, which has been extensively validated clinically.https://www.mdpi.com/2079-6374/12/5/333CO<sub>2</sub> partial pressuretranscutaneous sensorluminescent probeHPTSwearable device |
| spellingShingle | Juan Pedro Cascales Xiaolei Li Emmanuel Roussakis Conor L. Evans A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor Biosensors CO<sub>2</sub> partial pressure transcutaneous sensor luminescent probe HPTS wearable device |
| title | A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor |
| title_full | A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor |
| title_fullStr | A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor |
| title_full_unstemmed | A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor |
| title_short | A Patient-Ready Wearable Transcutaneous CO<sub>2</sub> Sensor |
| title_sort | patient ready wearable transcutaneous co sub 2 sub sensor |
| topic | CO<sub>2</sub> partial pressure transcutaneous sensor luminescent probe HPTS wearable device |
| url | https://www.mdpi.com/2079-6374/12/5/333 |
| work_keys_str_mv | AT juanpedrocascales apatientreadywearabletranscutaneouscosub2subsensor AT xiaoleili apatientreadywearabletranscutaneouscosub2subsensor AT emmanuelroussakis apatientreadywearabletranscutaneouscosub2subsensor AT conorlevans apatientreadywearabletranscutaneouscosub2subsensor AT juanpedrocascales patientreadywearabletranscutaneouscosub2subsensor AT xiaoleili patientreadywearabletranscutaneouscosub2subsensor AT emmanuelroussakis patientreadywearabletranscutaneouscosub2subsensor AT conorlevans patientreadywearabletranscutaneouscosub2subsensor |