Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood–brain barrier (BBB), which makes it difficult to find effective treatments and drugs, causing great stress and financial burden to familie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1184435/full |
| _version_ | 1827922288943562752 |
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| author | Renjie Pan Renjie Pan Dongdong Chen Dongdong Chen Lanlan Hou Lanlan Hou Rong Hu Zhigang Jiao Zhigang Jiao Zhigang Jiao |
| author_facet | Renjie Pan Renjie Pan Dongdong Chen Dongdong Chen Lanlan Hou Lanlan Hou Rong Hu Zhigang Jiao Zhigang Jiao Zhigang Jiao |
| author_sort | Renjie Pan |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood–brain barrier (BBB), which makes it difficult to find effective treatments and drugs, causing great stress and financial burden to families and society. Currently, small extracellular vesicles (sEVs) are the most promising drug delivery systems (DDSs) for targeted delivery of molecules to specific sites in the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, high stability, high delivery efficiency, high biocompatibility and trans-BBB functionality. Here, we review the therapeutic application of sEVs in several NDs, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, discuss the current barriers associated with sEVs and brain-targeted DDS, and suggest future research directions. |
| first_indexed | 2024-03-13T04:39:32Z |
| format | Article |
| id | doaj.art-9c30cebffabb4d9aa1c5c8112e1123fd |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-13T04:39:32Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9c30cebffabb4d9aa1c5c8112e1123fd2023-06-19T06:31:35ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-06-011510.3389/fnagi.2023.11844351184435Small extracellular vesicles: a novel drug delivery system for neurodegenerative disordersRenjie Pan0Renjie Pan1Dongdong Chen2Dongdong Chen3Lanlan Hou4Lanlan Hou5Rong Hu6Zhigang Jiao7Zhigang Jiao8Zhigang Jiao9First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaFirst Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaPrecision Medicine Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, ChinaNeurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood–brain barrier (BBB), which makes it difficult to find effective treatments and drugs, causing great stress and financial burden to families and society. Currently, small extracellular vesicles (sEVs) are the most promising drug delivery systems (DDSs) for targeted delivery of molecules to specific sites in the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, high stability, high delivery efficiency, high biocompatibility and trans-BBB functionality. Here, we review the therapeutic application of sEVs in several NDs, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, discuss the current barriers associated with sEVs and brain-targeted DDS, and suggest future research directions.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1184435/fullsmall extracellular vesiclesdrug delivery systemneurodegenerative diseasesbrain targetingblood–brain barriertreatment |
| spellingShingle | Renjie Pan Renjie Pan Dongdong Chen Dongdong Chen Lanlan Hou Lanlan Hou Rong Hu Zhigang Jiao Zhigang Jiao Zhigang Jiao Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders Frontiers in Aging Neuroscience small extracellular vesicles drug delivery system neurodegenerative diseases brain targeting blood–brain barrier treatment |
| title | Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders |
| title_full | Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders |
| title_fullStr | Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders |
| title_full_unstemmed | Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders |
| title_short | Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders |
| title_sort | small extracellular vesicles a novel drug delivery system for neurodegenerative disorders |
| topic | small extracellular vesicles drug delivery system neurodegenerative diseases brain targeting blood–brain barrier treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1184435/full |
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