Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone
AbstractBackground Pigment gallstones are not uncommon among patients with chronic haemolytic anaemia. But their clinical characteristics have not been described in detail and not been directly compared with the general gallstone population.Methods Patients at Peking Union Medical College Hospital w...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2203514 |
| _version_ | 1797353751910023168 |
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| author | Ziqi Wan Xiaoyin Bai Chengqing He Yueyi Zhang Ying Wang Kaini Shen Li Meizi Qiang Wang Wu Dongsheng Yunlu Feng Aiming Yang |
| author_facet | Ziqi Wan Xiaoyin Bai Chengqing He Yueyi Zhang Ying Wang Kaini Shen Li Meizi Qiang Wang Wu Dongsheng Yunlu Feng Aiming Yang |
| author_sort | Ziqi Wan |
| collection | DOAJ |
| description | AbstractBackground Pigment gallstones are not uncommon among patients with chronic haemolytic anaemia. But their clinical characteristics have not been described in detail and not been directly compared with the general gallstone population.Methods Patients at Peking Union Medical College Hospital with haemolytic anaemia and subsequent gallstones from January 2012 to December 2022 were included. Cases were matched (1:2) based on age, sex and location of stones to randomly select non-anaemia patients with gallstones (controls).Results Screening 899 cases of gallstones, we finally included 76 cases and 152 controls. Total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) for cases were 3.02 ± 0.98 mmol/L, 0.89 ± 0.30 mmol/L and 1.58 ± 0.70 mmol/L, respectively, significantly lower than those in the control group (all p < 0.001). TC and HDL were both lower than the normal range, but triglyceride and LDL were within the normal range. Multiple stones were significantly more common for cases (n = 59, 78%) than for controls (n = 44, 29%, p < 0.001). The mean diameter of the maximal gallstone was 1.2 ± 0.6 cm and 1.5 ± 1.0 cm for cases and controls (p = 0.120), respectively. Stones in the elderly (p = 0.002 for univariate analysis, and 0.001 for multivariate analysis) and stones in the bile duct (p = 0.005 for univariate analysis, and 0.009 for multivariate analysis) were found to occur in a shorter period after anaemia.Conclusion The lipid profile of haemolytic anaemia with gallstones was distinct, low TC, low HDL, and increased-to-normal LDL, compared with the general gallstone population. Patients with haemolytic anaemia were recommended an abdominal ultrasound if aged older than 50 years, with more frequent follow-up visits.KEY MESSAGESClinical characteristics of gallstones following chronic haemolytic anaemia were described and compared with the general gallstone population.The lipid profiles were distinctly different between the patients with gallstones following chronic haemolytic anaemia and the general gallstone population.Elder patients were complicated with gallstones in a shorter period after anaemia and thus were recommended an abdominal ultrasound if aged older than 50 years, with more frequent follow-up visits. |
| first_indexed | 2024-03-08T13:34:32Z |
| format | Article |
| id | doaj.art-9c3973705ba54b1087ee5c17ca9d9fe9 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:32Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-9c3973705ba54b1087ee5c17ca9d9fe92024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2203514Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstoneZiqi Wan0Xiaoyin Bai1Chengqing He2Yueyi Zhang3Ying Wang4Kaini Shen5Li Meizi6Qiang Wang7Wu Dongsheng8Yunlu Feng9Aiming Yang10Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaEight-Year Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Ultrasound, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaAbstractBackground Pigment gallstones are not uncommon among patients with chronic haemolytic anaemia. But their clinical characteristics have not been described in detail and not been directly compared with the general gallstone population.Methods Patients at Peking Union Medical College Hospital with haemolytic anaemia and subsequent gallstones from January 2012 to December 2022 were included. Cases were matched (1:2) based on age, sex and location of stones to randomly select non-anaemia patients with gallstones (controls).Results Screening 899 cases of gallstones, we finally included 76 cases and 152 controls. Total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) for cases were 3.02 ± 0.98 mmol/L, 0.89 ± 0.30 mmol/L and 1.58 ± 0.70 mmol/L, respectively, significantly lower than those in the control group (all p < 0.001). TC and HDL were both lower than the normal range, but triglyceride and LDL were within the normal range. Multiple stones were significantly more common for cases (n = 59, 78%) than for controls (n = 44, 29%, p < 0.001). The mean diameter of the maximal gallstone was 1.2 ± 0.6 cm and 1.5 ± 1.0 cm for cases and controls (p = 0.120), respectively. Stones in the elderly (p = 0.002 for univariate analysis, and 0.001 for multivariate analysis) and stones in the bile duct (p = 0.005 for univariate analysis, and 0.009 for multivariate analysis) were found to occur in a shorter period after anaemia.Conclusion The lipid profile of haemolytic anaemia with gallstones was distinct, low TC, low HDL, and increased-to-normal LDL, compared with the general gallstone population. Patients with haemolytic anaemia were recommended an abdominal ultrasound if aged older than 50 years, with more frequent follow-up visits.KEY MESSAGESClinical characteristics of gallstones following chronic haemolytic anaemia were described and compared with the general gallstone population.The lipid profiles were distinctly different between the patients with gallstones following chronic haemolytic anaemia and the general gallstone population.Elder patients were complicated with gallstones in a shorter period after anaemia and thus were recommended an abdominal ultrasound if aged older than 50 years, with more frequent follow-up visits.https://www.tandfonline.com/doi/10.1080/07853890.2023.2203514Gallstoneshaemolytic anaemiahypocholesterolemiahypolipidaemia |
| spellingShingle | Ziqi Wan Xiaoyin Bai Chengqing He Yueyi Zhang Ying Wang Kaini Shen Li Meizi Qiang Wang Wu Dongsheng Yunlu Feng Aiming Yang Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone Annals of Medicine Gallstones haemolytic anaemia hypocholesterolemia hypolipidaemia |
| title | Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone |
| title_full | Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone |
| title_fullStr | Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone |
| title_full_unstemmed | Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone |
| title_short | Distinct lipid profile in haemolytic anaemia-related gallstones compared with the general gallstone |
| title_sort | distinct lipid profile in haemolytic anaemia related gallstones compared with the general gallstone |
| topic | Gallstones haemolytic anaemia hypocholesterolemia hypolipidaemia |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2203514 |
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