A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (ME...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Karger Publishers
2019-10-01
|
Series: | Case Reports in Ophthalmology |
Subjects: | |
Online Access: | https://www.karger.com/Article/FullText/503414 |
_version_ | 1818025951009701888 |
---|---|
author | John R. Chancellor David A. Kilgore Ahmed B. Sallam Richard C. Allen Sami H. Uwaydat |
author_facet | John R. Chancellor David A. Kilgore Ahmed B. Sallam Richard C. Allen Sami H. Uwaydat |
author_sort | John R. Chancellor |
collection | DOAJ |
description | The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (MEKAR). MEKAR has classically been described as self-limiting, with serous fluid often resolving without discontinuation of the drug. We present a case in which a patient undergoing treatment for metastatic melanoma with lacnotuzumab, a macrophage colony-stimulating factor inhibitor that blocks an upstream component of the mitogen-activated protein kinase pathway, developed serous retinopathy that did not resolve despite drug discontinuation. |
first_indexed | 2024-12-10T04:24:16Z |
format | Article |
id | doaj.art-9c39d69f8109496da539fcf59c251044 |
institution | Directory Open Access Journal |
issn | 1663-2699 |
language | English |
last_indexed | 2024-12-10T04:24:16Z |
publishDate | 2019-10-01 |
publisher | Karger Publishers |
record_format | Article |
series | Case Reports in Ophthalmology |
spelling | doaj.art-9c39d69f8109496da539fcf59c2510442022-12-22T02:02:20ZengKarger PublishersCase Reports in Ophthalmology1663-26992019-10-0110333433810.1159/000503414503414A Case of Non-Resolving MEK Inhibitor-Associated RetinopathyJohn R. ChancellorDavid A. KilgoreAhmed B. SallamRichard C. AllenSami H. UwaydatThe mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (MEKAR). MEKAR has classically been described as self-limiting, with serous fluid often resolving without discontinuation of the drug. We present a case in which a patient undergoing treatment for metastatic melanoma with lacnotuzumab, a macrophage colony-stimulating factor inhibitor that blocks an upstream component of the mitogen-activated protein kinase pathway, developed serous retinopathy that did not resolve despite drug discontinuation.https://www.karger.com/Article/FullText/503414paraneoplastic vitelliform retinopathymelanomamek inhibitor |
spellingShingle | John R. Chancellor David A. Kilgore Ahmed B. Sallam Richard C. Allen Sami H. Uwaydat A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy Case Reports in Ophthalmology paraneoplastic vitelliform retinopathy melanoma mek inhibitor |
title | A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy |
title_full | A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy |
title_fullStr | A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy |
title_full_unstemmed | A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy |
title_short | A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy |
title_sort | case of non resolving mek inhibitor associated retinopathy |
topic | paraneoplastic vitelliform retinopathy melanoma mek inhibitor |
url | https://www.karger.com/Article/FullText/503414 |
work_keys_str_mv | AT johnrchancellor acaseofnonresolvingmekinhibitorassociatedretinopathy AT davidakilgore acaseofnonresolvingmekinhibitorassociatedretinopathy AT ahmedbsallam acaseofnonresolvingmekinhibitorassociatedretinopathy AT richardcallen acaseofnonresolvingmekinhibitorassociatedretinopathy AT samihuwaydat acaseofnonresolvingmekinhibitorassociatedretinopathy AT johnrchancellor caseofnonresolvingmekinhibitorassociatedretinopathy AT davidakilgore caseofnonresolvingmekinhibitorassociatedretinopathy AT ahmedbsallam caseofnonresolvingmekinhibitorassociatedretinopathy AT richardcallen caseofnonresolvingmekinhibitorassociatedretinopathy AT samihuwaydat caseofnonresolvingmekinhibitorassociatedretinopathy |