A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy

The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (ME...

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Main Authors: John R. Chancellor, David A. Kilgore, Ahmed B. Sallam, Richard C. Allen, Sami H. Uwaydat
Format: Article
Language:English
Published: Karger Publishers 2019-10-01
Series:Case Reports in Ophthalmology
Subjects:
Online Access:https://www.karger.com/Article/FullText/503414
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author John R. Chancellor
David A. Kilgore
Ahmed B. Sallam
Richard C. Allen
Sami H. Uwaydat
author_facet John R. Chancellor
David A. Kilgore
Ahmed B. Sallam
Richard C. Allen
Sami H. Uwaydat
author_sort John R. Chancellor
collection DOAJ
description The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (MEKAR). MEKAR has classically been described as self-limiting, with serous fluid often resolving without discontinuation of the drug. We present a case in which a patient undergoing treatment for metastatic melanoma with lacnotuzumab, a macrophage colony-stimulating factor inhibitor that blocks an upstream component of the mitogen-activated protein kinase pathway, developed serous retinopathy that did not resolve despite drug discontinuation.
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spelling doaj.art-9c39d69f8109496da539fcf59c2510442022-12-22T02:02:20ZengKarger PublishersCase Reports in Ophthalmology1663-26992019-10-0110333433810.1159/000503414503414A Case of Non-Resolving MEK Inhibitor-Associated RetinopathyJohn R. ChancellorDavid A. KilgoreAhmed B. SallamRichard C. AllenSami H. UwaydatThe mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in a new entity termed MEK inhibitor-associated retinopathy (MEKAR). MEKAR has classically been described as self-limiting, with serous fluid often resolving without discontinuation of the drug. We present a case in which a patient undergoing treatment for metastatic melanoma with lacnotuzumab, a macrophage colony-stimulating factor inhibitor that blocks an upstream component of the mitogen-activated protein kinase pathway, developed serous retinopathy that did not resolve despite drug discontinuation.https://www.karger.com/Article/FullText/503414paraneoplastic vitelliform retinopathymelanomamek inhibitor
spellingShingle John R. Chancellor
David A. Kilgore
Ahmed B. Sallam
Richard C. Allen
Sami H. Uwaydat
A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
Case Reports in Ophthalmology
paraneoplastic vitelliform retinopathy
melanoma
mek inhibitor
title A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
title_full A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
title_fullStr A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
title_full_unstemmed A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
title_short A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
title_sort case of non resolving mek inhibitor associated retinopathy
topic paraneoplastic vitelliform retinopathy
melanoma
mek inhibitor
url https://www.karger.com/Article/FullText/503414
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