Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages

Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages

Metabolic disorders (i.e., hyperglycemia, hyperlipidemia, and hyperinsulinemia) cause increased secretion of inflammatory cytokines/chemokines, leading to gradual loss of cardiac resident macrophage population and increased accumulation of inflammatory monocytes/macrophages in the heart. Such self-p...

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Bibliographic Details
Main Authors: Qianqian Li, Yutian Li, Wei Huang, Xiaohong Wang, Zhenling Liu, Jing Chen, Yanbo Fan, Tianqing Peng, Sakthivel Sadayappan, Yigang Wang, Guo-Chang Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
macrophage
lipocalin
diabetes
cardiac function
Nr4a1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.930397/full

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