Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats
Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition “Metovitan” given with anti-TB...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2013-04-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Anisimova_2_13.pdf |
| _version_ | 1797668782517256192 |
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| author | S. I. Anisimova G. V. Donchenko Yu. M. Parkhomenko V. M. Kovalenko |
| author_facet | S. I. Anisimova G. V. Donchenko Yu. M. Parkhomenko V. M. Kovalenko |
| author_sort | S. I. Anisimova |
| collection | DOAJ |
| description | Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition “Metovitan” given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation. “Metovitan” normalizes the enzymatic activity and content of total billirubin in the blood serum, shows high hepatoprotective properties, exceeding the efficiency of methionine. |
| first_indexed | 2024-03-11T20:34:30Z |
| format | Article |
| id | doaj.art-9c3a87bdc8634e11bf6a0d3cc4b23310 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T20:34:30Z |
| publishDate | 2013-04-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-9c3a87bdc8634e11bf6a0d3cc4b233102023-10-02T07:19:18ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032013-04-01852596710.15407/ubj85.02.059Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to ratsS. I. Anisimova0G. V. Donchenko1Yu. M. Parkhomenko2V. M. Kovalenko3SI Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivSI Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, KyivOral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition “Metovitan” given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation. “Metovitan” normalizes the enzymatic activity and content of total billirubin in the blood serum, shows high hepatoprotective properties, exceeding the efficiency of methionine.http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Anisimova_2_13.pdf"Metovitan"antituberculosis drugsCYP2E1CYP2С23CYP3A2cytochrome P-450hepatotoxicity |
| spellingShingle | S. I. Anisimova G. V. Donchenko Yu. M. Parkhomenko V. M. Kovalenko Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats The Ukrainian Biochemical Journal "Metovitan" antituberculosis drugs CYP2E1 CYP2С23 CYP3A2 cytochrome P-450 hepatotoxicity |
| title | Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats |
| title_full | Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats |
| title_fullStr | Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats |
| title_full_unstemmed | Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats |
| title_short | Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats |
| title_sort | mechanism of hepatoprotective action of methionine and composition metovitan against a background of antituberculosis drugs administration to rats |
| topic | "Metovitan" antituberculosis drugs CYP2E1 CYP2С23 CYP3A2 cytochrome P-450 hepatotoxicity |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Anisimova_2_13.pdf |
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