Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats

Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats

Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition “Metovitan” given with anti-TB...

Full description

Bibliographic Details
Main Authors:	S. I. Anisimova, G. V. Donchenko, Yu. M. Parkhomenko, V. M. Kovalenko
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2013-04-01
Series:	The Ukrainian Biochemical Journal
Subjects:	"Metovitan" antituberculosis drugs CYP2E1 CYP2С23 CYP3A2 cytochrome P-450 hepatotoxicity
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Anisimova_2_13.pdf

Similar Items

Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review
by: Kenza Mansoor, et al.
Published: (2023-02-01)

NAT2 and CYP2E1 polymorphisms and antituberculosis drug‐induced hepatotoxicity in Peruvian patients
by: Luis Jaramillo‐Valverde, et al.
Published: (2022-08-01)

Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification
by: Kata W. Pedersen, et al.
Published: (2021-10-01)

Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population
by: Asif Jan, et al.
Published: (2023-08-01)

Pharmacogenomics in Psychiatry Practice: The Value and the Challenges
by: Aminah Alchakee, et al.
Published: (2022-11-01)

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
by: Renata dos Santos Coura, et al.
Published: (2007-01-01)

METOVITAN PREVENTS THE ACCUMULATION OF THIAMINE DIPHOSPHATE OXIDIZED FORM IN RAT TISSUES UNDER IRRADIATION
by: Parkhomenko Yu. M., et al.
Published: (2015-08-01)

Frequencies of Combined Dysfunction of Cytochromes P450 2C9, 2C19, and 2D6 in an Italian Cohort: Suggestions for a More Appropriate Medication Prescribing Process
by: Giovanna Gentile, et al.
Published: (2023-08-01)

CYP2C9, CYPC19 and CYP2D6 gene profiles and gene susceptibility to drug response and toxicity in Turkish population
by: Merve Arici, et al.
Published: (2017-03-01)

A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species
by: Lorenzo Pedroni, et al.
Published: (2023-01-01)

Pharmacogenetics in Psychiatry: An Update on Clinical Usability
by: Ron H. N. van Schaik, et al.
Published: (2020-09-01)

Variability Between Clinical Pharmacogenetics Implementation Consortium (CPIC®) Guidelines and a Commercial Pharmacogenetics Laboratory in Genotype to Phenotype Interpretations For Patients Utilizing Psychotropics
by: Christopher Blazy, et al.
Published: (2022-06-01)

The genetic profiles of CYP1A1, CYP1A2 and CYP2E1 enzymes as susceptibility factor in xenobiotic toxicity in Turkish population
by: Merve Arici, et al.
Published: (2017-02-01)

Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
by: Mingwei Wang, et al.
Published: (2020-01-01)

CYP2C19 and CYP2D6 Genotypes and Metabolizer Status Distribution in a Bulgarian Psychiatric Cohort
by: Hristo Y. Ivanov, et al.
Published: (2022-07-01)

Mutual Influence of Human Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases on Their Respective Activities in Recombinant Fission Yeast
by: Sangeeta Shrestha Sharma, et al.
Published: (2023-01-01)

Cytochrome P450 genes expression in human prostate cancer
by: Oksana Maksymchuk, et al.
Published: (2024-03-01)

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies
by: Smarakan Sneha, et al.
Published: (2021-03-01)

β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration
by: Jesus Fernandez-Abascal, et al.
Published: (2020-05-01)

Exploring the Chemical Space of Cytochrome P450 Inhibitors using Integrated Physicochemical Parameters, Drug Efficiency Metrics and Decision Tree Models
by: Yusra Sajid Kiani, et al.
Published: (2019-05-01)

Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study
by: Megan E. Solan, et al.
Published: (2023-01-01)

Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population
by: Débora Christina Ricardo Oliveira Fernandes, et al.
Published: (2015-04-01)

Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes
by: D. V. Ivashchenko, et al.
Published: (2020-12-01)

Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan
by: Sagheer Ahmed, et al.
Published: (2020-08-01)

VDR, SOD-2, and CYP24A1 Gene Expression in Different Genotypes of BsmI SNP of the Vitamin D Receptor Gene in Individuals with Hypovitaminosis
by: Vanessa Rosa Retamoso, et al.
Published: (2023-08-01)

Evidence-based capacity of natural cytochrome enzyme inhibitors to increase the effectivity of antineoplastic drugs
by: Laxmi Manthalkar, et al.
Published: (2022-12-01)

The molecular pathogenesis of triptolide-induced hepatotoxicity
by: Yeqing Hu, et al.
Published: (2022-08-01)

CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms
by: Ohgew Kweon, et al.
Published: (2020-04-01)

Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase
by: Shaheena Parween, et al.
Published: (2019-10-01)

The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncomplicated Acute Calculous Cholecystitis Who Underwent Cholecystectomy
by: A. A. Muradyan, et al.
Published: (2020-10-01)

An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types
by: Miho Nakano, et al.
Published: (2023-12-01)

Modulatory effects of Benjakul extract on rat hepatic cytochrome P450 enzymes
by: Suchittra Samuhasaneeto, et al.
Published: (2021-11-01)

Molecular Dynamics Simulations of a Cytochrome P450 from <i>Tepidiphilus thermophilus</i> (P450-TT) Reveal How Its Substrate-Binding Channel Opens
by: Abayomi S. Faponle, et al.
Published: (2021-06-01)

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni
by: Anne E Lockyer, et al.
Published: (2005-05-01)

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations
by: Ann K. Daly, et al.
Published: (2017-12-01)

Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping
by: Sang Won Han, et al.
Published: (2017-09-01)

Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and ß-ionone in rat tissues
by: A.B. Robottom-Ferreira, et al.
Published: (2003-07-01)

CYP2D6 Genotype-Based Dose Recommendations for Risperidone in Asian People
by: Yuanxia Cui, et al.
Published: (2020-08-01)

Determination of the activity of drug-metabolizing enzymes - the prospects for their use in clinical practice
by: V. V. Smirnov, et al.
Published: (2018-02-01)

Drug–Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes
by: Florian Klomp, et al.
Published: (2020-12-01)