Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog
Canine distemper virus (CDV) is a major viral pathogen in domestic dogs, belonging to the <i>Paramyxoviridae</i> family, in the <i>Morbillivirus</i> genus. It is present worldwide, and a wide range of domestic animals and wild carnivores are at risk. In the absence of vaccina...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/4/61 |
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| author | Zsófia Lanszki Brigitta Zana Safia Zeghbib Ferenc Jakab Nikoletta Szabó Gábor Kemenesi |
| author_facet | Zsófia Lanszki Brigitta Zana Safia Zeghbib Ferenc Jakab Nikoletta Szabó Gábor Kemenesi |
| author_sort | Zsófia Lanszki |
| collection | DOAJ |
| description | Canine distemper virus (CDV) is a major viral pathogen in domestic dogs, belonging to the <i>Paramyxoviridae</i> family, in the <i>Morbillivirus</i> genus. It is present worldwide, and a wide range of domestic animals and wild carnivores are at risk. In the absence of vaccination, dogs have a low chance of survival; however, if and when a dog survives, it can take an average of a few weeks to a few months to fully wipe out the virus. In the present study, we traced the course of infection of a 1-year-old mixed-breed male dog. The animal had an unusually long course of persistent CDV infection with a vector-borne heartworm (<i>Dirofilaria immitis</i>) co-infection. The dog excreted the CDV for 17 months with PCR positivity in urine samples collected from February 2019 through June 2020. The sequencing and phylogenetic analysis of the hemagglutinin gene revealed the CDV to be the member of the endemic Arctic-like genetic lineage. To the best of our knowledge, this report represents the longest documented canine infection of CDV. Notably, we highlight the necessity regarding CDV infectivity studies to better comprehend the transmission attributes of the virus. |
| first_indexed | 2024-03-10T12:25:17Z |
| format | Article |
| id | doaj.art-9c3bc53273ac410b8ade9fa1db74eb77 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T12:25:17Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-9c3bc53273ac410b8ade9fa1db74eb772023-11-21T15:06:28ZengMDPI AGVeterinary Sciences2306-73812021-04-01846110.3390/vetsci8040061Prolonged Infection of Canine Distemper Virus in a Mixed-Breed DogZsófia Lanszki0Brigitta Zana1Safia Zeghbib2Ferenc Jakab3Nikoletta Szabó4Gábor Kemenesi5National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryCorden International Hungary Ltd., 1117 Budapest, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryCanine distemper virus (CDV) is a major viral pathogen in domestic dogs, belonging to the <i>Paramyxoviridae</i> family, in the <i>Morbillivirus</i> genus. It is present worldwide, and a wide range of domestic animals and wild carnivores are at risk. In the absence of vaccination, dogs have a low chance of survival; however, if and when a dog survives, it can take an average of a few weeks to a few months to fully wipe out the virus. In the present study, we traced the course of infection of a 1-year-old mixed-breed male dog. The animal had an unusually long course of persistent CDV infection with a vector-borne heartworm (<i>Dirofilaria immitis</i>) co-infection. The dog excreted the CDV for 17 months with PCR positivity in urine samples collected from February 2019 through June 2020. The sequencing and phylogenetic analysis of the hemagglutinin gene revealed the CDV to be the member of the endemic Arctic-like genetic lineage. To the best of our knowledge, this report represents the longest documented canine infection of CDV. Notably, we highlight the necessity regarding CDV infectivity studies to better comprehend the transmission attributes of the virus.https://www.mdpi.com/2306-7381/8/4/61<i>Paramyxoviridae</i><i>Morbillivirus</i>canine distemper virushaemagglutinin genearctic-like lineagedomestic dog |
| spellingShingle | Zsófia Lanszki Brigitta Zana Safia Zeghbib Ferenc Jakab Nikoletta Szabó Gábor Kemenesi Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog Veterinary Sciences <i>Paramyxoviridae</i> <i>Morbillivirus</i> canine distemper virus haemagglutinin gene arctic-like lineage domestic dog |
| title | Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog |
| title_full | Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog |
| title_fullStr | Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog |
| title_full_unstemmed | Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog |
| title_short | Prolonged Infection of Canine Distemper Virus in a Mixed-Breed Dog |
| title_sort | prolonged infection of canine distemper virus in a mixed breed dog |
| topic | <i>Paramyxoviridae</i> <i>Morbillivirus</i> canine distemper virus haemagglutinin gene arctic-like lineage domestic dog |
| url | https://www.mdpi.com/2306-7381/8/4/61 |
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