Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant
PURPOSE: To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. METHODS: A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implant...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014-01-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300004&tlng=en |
| _version_ | 1818906618453032960 |
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| author | Leandro de Borborema Garcia Armando da Silva Cunha Junior Silvia Ligório Fialho André Coura Perez Bruno Borges de Carvalho Barros Ricardo Schaffeln Dorigueto José Ricardo Gurgel Testa |
| author_facet | Leandro de Borborema Garcia Armando da Silva Cunha Junior Silvia Ligório Fialho André Coura Perez Bruno Borges de Carvalho Barros Ricardo Schaffeln Dorigueto José Ricardo Gurgel Testa |
| author_sort | Leandro de Borborema Garcia |
| collection | DOAJ |
| description | PURPOSE: To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. METHODS: A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively). RESULTS: Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2. CONCLUSION: The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant. |
| first_indexed | 2024-12-19T21:42:05Z |
| format | Article |
| id | doaj.art-9c3cf83c460040c58d6fc35ebbb67f63 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-19T21:42:05Z |
| publishDate | 2014-01-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-9c3cf83c460040c58d6fc35ebbb67f632022-12-21T20:04:38ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502014-01-0129suppl 1121810.1590/S0102-86502014001300003Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implantLeandro de Borborema GarciaArmando da Silva Cunha JuniorSilvia Ligório FialhoAndré Coura PerezBruno Borges de Carvalho BarrosRicardo Schaffeln DoriguetoJosé Ricardo Gurgel TestaPURPOSE: To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. METHODS: A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively). RESULTS: Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2. CONCLUSION: The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300004&tlng=enBiopolymersInflammationEar, MiddleGuinea Pigs |
| spellingShingle | Leandro de Borborema Garcia Armando da Silva Cunha Junior Silvia Ligório Fialho André Coura Perez Bruno Borges de Carvalho Barros Ricardo Schaffeln Dorigueto José Ricardo Gurgel Testa Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant Acta Cirúrgica Brasileira Biopolymers Inflammation Ear, Middle Guinea Pigs |
| title | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant |
| title_full | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant |
| title_fullStr | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant |
| title_full_unstemmed | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant |
| title_short | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant |
| title_sort | tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs when receiving biodegradable implant |
| topic | Biopolymers Inflammation Ear, Middle Guinea Pigs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001300004&tlng=en |
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