Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration

Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration

Microbial colonization of the gut early in life is crucial for the development of the immune and nervous systems, as well as influencing metabolism and weight gain. While early life exposure to antibiotics can cause microbial dysbiosis, prebiotics are non-digestible substrates that selectively promo...

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Bibliographic Details
Main Authors: Nicole A. Cho, Alissa C. Nicolucci, Teja Klancic, Weilan Wang, Keith A. Sharkey, Richelle Mychasiuk, Raylene A. Reimer
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Microorganisms
Subjects:
antibiotics
prebiotics
oligofructose
gut microbiota
behavior
Online Access:https://www.mdpi.com/2076-2607/8/7/1085

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