Pericytes: Problems and Promises for CNS Repair
Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also imp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00546/full |
| _version_ | 1818267387452981248 |
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| author | Fabio Laredo Fabio Laredo Julia Plebanski Andrea Tedeschi Andrea Tedeschi |
| author_facet | Fabio Laredo Fabio Laredo Julia Plebanski Andrea Tedeschi Andrea Tedeschi |
| author_sort | Fabio Laredo |
| collection | DOAJ |
| description | Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease. |
| first_indexed | 2024-12-12T20:21:47Z |
| format | Article |
| id | doaj.art-9c3e449ab08546578c4761e45740ea4f |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T20:21:47Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9c3e449ab08546578c4761e45740ea4f2022-12-22T00:13:14ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-12-011310.3389/fncel.2019.00546494089Pericytes: Problems and Promises for CNS RepairFabio Laredo0Fabio Laredo1Julia Plebanski2Andrea Tedeschi3Andrea Tedeschi4Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH, United StatesDepartment of Life Sciences, University of Nottingham, Nottingham, United KingdomDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH, United StatesDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH, United StatesDiscovery Theme on Chronic Brain Injury, The Ohio State University, Columbus, OH, United StatesMicrovascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease.https://www.frontiersin.org/article/10.3389/fncel.2019.00546/fullpericyteangiogenesisblood brain barrier (BBB)neurovascular inflammationfibrotic scaraxon regeneration |
| spellingShingle | Fabio Laredo Fabio Laredo Julia Plebanski Andrea Tedeschi Andrea Tedeschi Pericytes: Problems and Promises for CNS Repair Frontiers in Cellular Neuroscience pericyte angiogenesis blood brain barrier (BBB) neurovascular inflammation fibrotic scar axon regeneration |
| title | Pericytes: Problems and Promises for CNS Repair |
| title_full | Pericytes: Problems and Promises for CNS Repair |
| title_fullStr | Pericytes: Problems and Promises for CNS Repair |
| title_full_unstemmed | Pericytes: Problems and Promises for CNS Repair |
| title_short | Pericytes: Problems and Promises for CNS Repair |
| title_sort | pericytes problems and promises for cns repair |
| topic | pericyte angiogenesis blood brain barrier (BBB) neurovascular inflammation fibrotic scar axon regeneration |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00546/full |
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