Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism

Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism

An unusual aspect of actinobacterial metabolism is the use of the redox cofactor F420. Studies have shown that actinobacterial F420H2-dependent reductases promiscuously hydrogenate diverse organic compounds in biodegradative and biosynthetic processes. These enzymes therefore represent promising can...

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Bibliographic Details
Main Authors: Chris Greening, Thanavit Jirapanjawat, Shahana Afroze, Blair Ney, Colin Scott, Gunjan Pandey, Brendon M. Lee, Robyn J. Russell, Colin J. Jackson, John G. Oakeshott, Matthew C. Taylor, Andrew C. Warden
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
F420
redox
biocatalysis
promiscuity
biodegradation
Mycobacterium
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01000/full

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