The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China
Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic method...
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| Format: | Article |
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MDPI AG
2014-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/10/16529 |
| _version_ | 1811322975024054272 |
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| author | Bin Chen Qiong Shen Xun Zhu Yongcheng Lin |
| author_facet | Bin Chen Qiong Shen Xun Zhu Yongcheng Lin |
| author_sort | Bin Chen |
| collection | DOAJ |
| description | Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively. |
| first_indexed | 2024-04-13T13:45:52Z |
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| id | doaj.art-9c3fda18fad3498981f407b6c9b2656d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T13:45:52Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-9c3fda18fad3498981f407b6c9b2656d2022-12-22T02:44:30ZengMDPI AGMolecules1420-30492014-10-011910165291654210.3390/molecules191016529molecules191016529The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, ChinaBin Chen0Qiong Shen1Xun Zhu2Yongcheng Lin3School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, ChinaZhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, ChinaFour new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively.http://www.mdpi.com/1420-3049/19/10/16529Alternariasecondary metabolitesanthraquinonesalterporriolsaltersolanolscytotoxicityenzyme inhibitory activity |
| spellingShingle | Bin Chen Qiong Shen Xun Zhu Yongcheng Lin The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China Molecules Alternaria secondary metabolites anthraquinones alterporriols altersolanols cytotoxicity enzyme inhibitory activity |
| title | The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China |
| title_full | The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China |
| title_fullStr | The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China |
| title_full_unstemmed | The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China |
| title_short | The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China |
| title_sort | anthraquinone derivatives from the fungus alternaria sp xzsbg 1 from the saline lake in bange tibet china |
| topic | Alternaria secondary metabolites anthraquinones alterporriols altersolanols cytotoxicity enzyme inhibitory activity |
| url | http://www.mdpi.com/1420-3049/19/10/16529 |
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