Insulin resistance in pathogenesis of type 2 diabetes mellitus
This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor le...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2011-03-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6248 |
| _version_ | 1797255292836118528 |
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| author | Alexander Yur'evich Mayorov |
| author_facet | Alexander Yur'evich Mayorov |
| author_sort | Alexander Yur'evich Mayorov |
| collection | DOAJ |
| description | This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed. |
| first_indexed | 2024-03-08T15:22:33Z |
| format | Article |
| id | doaj.art-9c40cd270214469baf7a8e1f2b6164f3 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:32Z |
| publishDate | 2011-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-9c40cd270214469baf7a8e1f2b6164f32024-03-20T11:47:56ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782011-03-01141354510.14341/2072-0351-62486206Insulin resistance in pathogenesis of type 2 diabetes mellitusAlexander Yur'evich Mayorov0Endocrinology Research Centre, MoscowThis review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed.https://www.dia-endojournals.ru/jour/article/view/6248insulin resistancetype 2 diabetes mellitusglucose utilization in tissuesm-indexdisturbed fasting glycemiaimpaired glucose tolerance |
| spellingShingle | Alexander Yur'evich Mayorov Insulin resistance in pathogenesis of type 2 diabetes mellitus Сахарный диабет insulin resistance type 2 diabetes mellitus glucose utilization in tissues m-index disturbed fasting glycemia impaired glucose tolerance |
| title | Insulin resistance in pathogenesis of type 2 diabetes mellitus |
| title_full | Insulin resistance in pathogenesis of type 2 diabetes mellitus |
| title_fullStr | Insulin resistance in pathogenesis of type 2 diabetes mellitus |
| title_full_unstemmed | Insulin resistance in pathogenesis of type 2 diabetes mellitus |
| title_short | Insulin resistance in pathogenesis of type 2 diabetes mellitus |
| title_sort | insulin resistance in pathogenesis of type 2 diabetes mellitus |
| topic | insulin resistance type 2 diabetes mellitus glucose utilization in tissues m-index disturbed fasting glycemia impaired glucose tolerance |
| url | https://www.dia-endojournals.ru/jour/article/view/6248 |
| work_keys_str_mv | AT alexanderyurevichmayorov insulinresistanceinpathogenesisoftype2diabetesmellitus |