Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus
Recently, mechanism study of hepatitis E virus (HEV) infection has attracted an increasing attention because of the growing rate of the acute hepatitis caused by the virus over the world. As an important initiate in the inflammation, mast cells (MCs) play a critical role in maintaining a healthy phy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02226/full |
| _version_ | 1818916631660724224 |
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| author | Tianlong Liu Peng Xiao Ruiwen Li Ruiping She Jijing Tian Jingyuan Wang Jingjing Mao Jun Yin Ruihan Shi |
| author_facet | Tianlong Liu Peng Xiao Ruiwen Li Ruiping She Jijing Tian Jingyuan Wang Jingjing Mao Jun Yin Ruihan Shi |
| author_sort | Tianlong Liu |
| collection | DOAJ |
| description | Recently, mechanism study of hepatitis E virus (HEV) infection has attracted an increasing attention because of the growing rate of the acute hepatitis caused by the virus over the world. As an important initiate in the inflammation, mast cells (MCs) play a critical role in maintaining a healthy physiology. However, the function of the MCs in the acute hepatitis caused by HEV is still unclear. In the present study, mongolian gerbils infected by HEV were used as an animal model to evaluate the role of MCs in the HEV infection. The positive ELISA and RT-PCR results showed the gerbils was successfully infected with HEV. The number of mast cell in the liver and the small intestine in the infected animals were growing higher significantly than the control group. In addition, higher expression of the tryptase and 5-HT in the liver and the intestine detected by immunohistochemical method and western blot also indicate the activation of MCs in the infection. These results suggest that MCs play an important role in the hepatitis E. |
| first_indexed | 2024-12-20T00:21:15Z |
| format | Article |
| id | doaj.art-9c40e4748ae9463bb82455b3d0e9b55e |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T00:21:15Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9c40e4748ae9463bb82455b3d0e9b55e2022-12-21T20:00:11ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-10-01910.3389/fmicb.2018.02226362067Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E VirusTianlong Liu0Peng Xiao1Ruiwen Li2Ruiping She3Jijing Tian4Jingyuan Wang5Jingjing Mao6Jun Yin7Ruihan Shi8Laboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaSanford School of Medicine, University of South Dakota, Vermillion, SD, United StatesCollege of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Dingzhou, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaRecently, mechanism study of hepatitis E virus (HEV) infection has attracted an increasing attention because of the growing rate of the acute hepatitis caused by the virus over the world. As an important initiate in the inflammation, mast cells (MCs) play a critical role in maintaining a healthy physiology. However, the function of the MCs in the acute hepatitis caused by HEV is still unclear. In the present study, mongolian gerbils infected by HEV were used as an animal model to evaluate the role of MCs in the HEV infection. The positive ELISA and RT-PCR results showed the gerbils was successfully infected with HEV. The number of mast cell in the liver and the small intestine in the infected animals were growing higher significantly than the control group. In addition, higher expression of the tryptase and 5-HT in the liver and the intestine detected by immunohistochemical method and western blot also indicate the activation of MCs in the infection. These results suggest that MCs play an important role in the hepatitis E.https://www.frontiersin.org/article/10.3389/fmicb.2018.02226/fullmongolian gerbilshepatitis E virusexperimental infectionmast cellactivation |
| spellingShingle | Tianlong Liu Peng Xiao Ruiwen Li Ruiping She Jijing Tian Jingyuan Wang Jingjing Mao Jun Yin Ruihan Shi Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus Frontiers in Microbiology mongolian gerbils hepatitis E virus experimental infection mast cell activation |
| title | Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus |
| title_full | Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus |
| title_fullStr | Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus |
| title_full_unstemmed | Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus |
| title_short | Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus |
| title_sort | increased mast cell activation in mongolian gerbils infected by hepatitis e virus |
| topic | mongolian gerbils hepatitis E virus experimental infection mast cell activation |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.02226/full |
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