Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings
BackgroundThe burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric popu...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.793326/full |
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| author | Qalab Abbas Adrian Holloway Paula Caporal Paula Caporal Eliana López-Barón Asya Agulnik Kenneth E. Remy Kenneth E. Remy John A. Appiah Jonah Attebery Ericka L. Fink Jan Hau Lee Jan Hau Lee Shubhada Hooli Niranjan Kissoon Erika Miller Srinivas Murthy Fiona Muttalib Katie Nielsen Maria Puerto-Torres Karla Rodrigues Firas Sakaan Adriana Teixeira Rodrigues Erica A. Tabor Amelie von Saint Andre-von Arnim Matthew O. Wiens Matthew O. Wiens Matthew O. Wiens William Blackwelder David He Teresa B. Kortz Teresa B. Kortz Adnan T. Bhutta Adnan T. Bhutta |
| author_facet | Qalab Abbas Adrian Holloway Paula Caporal Paula Caporal Eliana López-Barón Asya Agulnik Kenneth E. Remy Kenneth E. Remy John A. Appiah Jonah Attebery Ericka L. Fink Jan Hau Lee Jan Hau Lee Shubhada Hooli Niranjan Kissoon Erika Miller Srinivas Murthy Fiona Muttalib Katie Nielsen Maria Puerto-Torres Karla Rodrigues Firas Sakaan Adriana Teixeira Rodrigues Erica A. Tabor Amelie von Saint Andre-von Arnim Matthew O. Wiens Matthew O. Wiens Matthew O. Wiens William Blackwelder David He Teresa B. Kortz Teresa B. Kortz Adnan T. Bhutta Adnan T. Bhutta |
| author_sort | Qalab Abbas |
| collection | DOAJ |
| description | BackgroundThe burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric populations in RLS, development of a contextual framework for appropriate, evidence-based interventions to guide allocation of limited but available resources is challenging. We present this methods paper which describes our efforts to determine the prevalence, etiology, hospital outcomes, and resource utilization associated with pediatric acute, critical illness in RLS globally.MethodsWe will conduct a prospective, observational, multicenter, multinational point prevalence study in sixty-one participating RLS hospitals from North, Central and South America, Africa, Middle East and South Asia with four sampling time points over a 12-month period. Children aged 29 days to 14 years evaluated for acute illness or injury in an emergency department) or directly admitted to an inpatient unit will be enrolled and followed for hospital outcomes and resource utilization for the first seven days of hospitalization. The primary outcome will be prevalence of acute critical illness, which Global PARITY has defined as death within 48 hours of presentation to the hospital, including ED mortality; or admission/transfer to an HDU or ICU; or transfer to another institution for a higher level-of-care; or receiving critical care-level interventions (vasopressor infusion, invasive mechanical ventilation, non-invasive mechanical ventilation) regardless of location in the hospital, among children presenting to the hospital. Secondary outcomes include etiology of critical illness, in-hospital mortality, cause of death, resource utilization, length of hospital stay, and change in neurocognitive status. Data will be managed via REDCap, aggregated, and analyzed across sites.DiscussionThis study is expected to address the current gap in understanding of the burden, etiology, resource utilization and outcomes associated with pediatric acute and critical illness in RLS. These data are crucial to inform future research and clinical management decisions and to improve global pediatric hospital outcomes. |
| first_indexed | 2024-04-11T20:02:42Z |
| format | Article |
| id | doaj.art-9c41ad0075174ae79423d5a40ac66060 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T20:02:42Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-9c41ad0075174ae79423d5a40ac660602022-12-22T04:05:32ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-01-01910.3389/fped.2021.793326793326Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited SettingsQalab Abbas0Adrian Holloway1Paula Caporal2Paula Caporal3Eliana López-Barón4Asya Agulnik5Kenneth E. Remy6Kenneth E. Remy7John A. Appiah8Jonah Attebery9Ericka L. Fink10Jan Hau Lee11Jan Hau Lee12Shubhada Hooli13Niranjan Kissoon14Erika Miller15Srinivas Murthy16Fiona Muttalib17Katie Nielsen18Maria Puerto-Torres19Karla Rodrigues20Firas Sakaan21Adriana Teixeira Rodrigues22Erica A. Tabor23Amelie von Saint Andre-von Arnim24Matthew O. Wiens25Matthew O. Wiens26Matthew O. Wiens27William Blackwelder28David He29Teresa B. Kortz30Teresa B. Kortz31Adnan T. Bhutta32Adnan T. Bhutta33Department of Pediatrics and Child Health, Aga Khan University Karachi, Karachi, PakistanDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD, United StatesHospital Interzonal Especializado en Pediatría “Sor María Ludovica”, La Plata, ArgentinaRed Colaborativa Pediátrica de Latinoamérica (LARed Network), Buenos Aires, ArgentinaHospital Pablo Tobón Uribe, Unidad de Cuidado Crítico Pediátrico, Medellín, ColombiaDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, United StatesDivision of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United StatesDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University Hospitals of Cleveland and Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, United StatesPediatric Intensive Care Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana0Department of Pediatrics, Section of Pediatric Critical Care, University of Colorado, Aurora, CO, United States1Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States2Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore, Singapore3SingHealth Duke-NUS Global Health Institute, Singapore, Singapore4Division of Pediatric Critical Care, Department of Pediatrics, BC Children's Hospital, The University of British Columbia, Vancouver, BC, Canada5Department of Pediatrics, Section of Pediatric Emergency Medicine, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United StatesDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD, United States5Department of Pediatrics, Section of Pediatric Emergency Medicine, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States5Department of Pediatrics, Section of Pediatric Emergency Medicine, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States6Division of Pediatric Critical Care, Department of Pediatrics, University of Washington, Seattle Children's, Seattle, WA, United StatesDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, United States7Department of Pediatrics, Hospital das Clínicas da UFMG/EBSERH, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, United States7Department of Pediatrics, Hospital das Clínicas da UFMG/EBSERH, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil8Pennsylvania State University, State College, PA, United States6Division of Pediatric Critical Care, Department of Pediatrics, University of Washington, Seattle Children's, Seattle, WA, United States9Center for Child Health at BC Children's Hospital, The University of British Columbia, Vancouver, BC, Canada0Department of Pediatrics, Mbarara University of Science and Technology, Mbarara, Uganda1Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada2Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, United States3Analytical Solutions Group, Inc., North Potomac, MD, United States4Division of Critical Care, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States5Institute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, United StatesDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD, United States6Center for Vaccine Development and Global Health, University of Maryland, Baltimore, MD, United StatesBackgroundThe burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric populations in RLS, development of a contextual framework for appropriate, evidence-based interventions to guide allocation of limited but available resources is challenging. We present this methods paper which describes our efforts to determine the prevalence, etiology, hospital outcomes, and resource utilization associated with pediatric acute, critical illness in RLS globally.MethodsWe will conduct a prospective, observational, multicenter, multinational point prevalence study in sixty-one participating RLS hospitals from North, Central and South America, Africa, Middle East and South Asia with four sampling time points over a 12-month period. Children aged 29 days to 14 years evaluated for acute illness or injury in an emergency department) or directly admitted to an inpatient unit will be enrolled and followed for hospital outcomes and resource utilization for the first seven days of hospitalization. The primary outcome will be prevalence of acute critical illness, which Global PARITY has defined as death within 48 hours of presentation to the hospital, including ED mortality; or admission/transfer to an HDU or ICU; or transfer to another institution for a higher level-of-care; or receiving critical care-level interventions (vasopressor infusion, invasive mechanical ventilation, non-invasive mechanical ventilation) regardless of location in the hospital, among children presenting to the hospital. Secondary outcomes include etiology of critical illness, in-hospital mortality, cause of death, resource utilization, length of hospital stay, and change in neurocognitive status. Data will be managed via REDCap, aggregated, and analyzed across sites.DiscussionThis study is expected to address the current gap in understanding of the burden, etiology, resource utilization and outcomes associated with pediatric acute and critical illness in RLS. These data are crucial to inform future research and clinical management decisions and to improve global pediatric hospital outcomes.https://www.frontiersin.org/articles/10.3389/fped.2021.793326/fullpediatric critical illnessacute pediatric carecritical careoutcomelow-and lower-middle-income countriesresource utilization |
| spellingShingle | Qalab Abbas Adrian Holloway Paula Caporal Paula Caporal Eliana López-Barón Asya Agulnik Kenneth E. Remy Kenneth E. Remy John A. Appiah Jonah Attebery Ericka L. Fink Jan Hau Lee Jan Hau Lee Shubhada Hooli Niranjan Kissoon Erika Miller Srinivas Murthy Fiona Muttalib Katie Nielsen Maria Puerto-Torres Karla Rodrigues Firas Sakaan Adriana Teixeira Rodrigues Erica A. Tabor Amelie von Saint Andre-von Arnim Matthew O. Wiens Matthew O. Wiens Matthew O. Wiens William Blackwelder David He Teresa B. Kortz Teresa B. Kortz Adnan T. Bhutta Adnan T. Bhutta Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings Frontiers in Pediatrics pediatric critical illness acute pediatric care critical care outcome low-and lower-middle-income countries resource utilization |
| title | Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings |
| title_full | Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings |
| title_fullStr | Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings |
| title_full_unstemmed | Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings |
| title_short | Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings |
| title_sort | global parity study design for a multi centered international point prevalence study to estimate the burden of pediatric acute critical illness in resource limited settings |
| topic | pediatric critical illness acute pediatric care critical care outcome low-and lower-middle-income countries resource utilization |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.793326/full |
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