<i>Ishige okamurae</i> Ameliorates Methylglyoxal-Induced Nephrotoxicity via Reducing Oxidative Stress, RAGE Protein Expression, and Modulating MAPK, Nrf2/ARE Signaling Pathway in Mouse Glomerular Mesangial Cells

<i>Ishige okamurae</i> Ameliorates Methylglyoxal-Induced Nephrotoxicity via Reducing Oxidative Stress, RAGE Protein Expression, and Modulating MAPK, Nrf2/ARE Signaling Pathway in Mouse Glomerular Mesangial Cells

Advanced glycation end-products (AGEs) such as methylglyoxal (MGO) play a vital role in the pathogenesis of nephropathy, a diabetic complication. In the present study, we evaluated the anti-glycation and renal protective properties of <i>Ishige okamurae</i> extract (IOE) against AGE-indu...

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Bibliographic Details
Main Authors: Mingyeong Kim, Chiheung Cho, Changjun Lee, Bomi Ryu, Sera Kim, Jinyoung Hur, Sang-Hoon Lee
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Foods
Subjects:
<i>Ishige okamurae</i>
advanced glycation end-product
nephropathy
methylglyoxal
Nrf2/ARE pathway
Online Access:https://www.mdpi.com/2304-8158/10/9/2000

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