Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022
Campylobacteriosis causes a significant disease burden in humans worldwide and is the most common type of zoonotic gastroenteritis in Finland. To identify infection sources for domestic <i>Campylobacter</i> infections, we analyzed <i>Campylobacter</i> case data from the Finni...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/12/1/132 |
| _version_ | 1797339627764318208 |
|---|---|
| author | Kristiina Suominen Tessa Häkkänen Jukka Ranta Jukka Ollgren Rauni Kivistö Päivikki Perko-Mäkelä Saara Salmenlinna Ruska Rimhanen-Finne |
| author_facet | Kristiina Suominen Tessa Häkkänen Jukka Ranta Jukka Ollgren Rauni Kivistö Päivikki Perko-Mäkelä Saara Salmenlinna Ruska Rimhanen-Finne |
| author_sort | Kristiina Suominen |
| collection | DOAJ |
| description | Campylobacteriosis causes a significant disease burden in humans worldwide and is the most common type of zoonotic gastroenteritis in Finland. To identify infection sources for domestic <i>Campylobacter</i> infections, we analyzed <i>Campylobacter</i> case data from the Finnish Infectious Disease Register (FIDR) in 2004–2021 and outbreak data from the National Food- and Waterborne Outbreak Register (FWO Register) in 2010–2021, and conducted a pilot case-control study (256 cases and 756 controls) with source attribution and patient sample analysis using whole-genome sequencing (WGS) in July–August 2022. In the FIDR, 41% of the cases lacked information on travel history. Based on the case-control study, we estimated that of all cases, 39% were of domestic origin. Using WGS, 22 clusters of two or more cases were observed among 185 domestic cases, none of which were reported to the FWO register. Based on this case-control study and source attribution, poultry is an important source of campylobacteriosis in Finland. More extensive sampling and comparison of patient, food, animal, and environmental isolates is needed to estimate the significance of other sources. In Finland, campylobacteriosis is more often of domestic origin than FIDR notifications indicate. To identify the domestic cases, travel information should be included in the FIDR notification, and to improve outbreak detection, all domestic patient isolates should be sequenced. |
| first_indexed | 2024-03-08T09:49:58Z |
| format | Article |
| id | doaj.art-9c42319d54c84cf8908fbcf4cb5857a3 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T09:49:58Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9c42319d54c84cf8908fbcf4cb5857a32024-01-29T14:06:30ZengMDPI AGMicroorganisms2076-26072024-01-0112113210.3390/microorganisms12010132Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022Kristiina Suominen0Tessa Häkkänen1Jukka Ranta2Jukka Ollgren3Rauni Kivistö4Päivikki Perko-Mäkelä5Saara Salmenlinna6Ruska Rimhanen-Finne7Department of Health Security, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00271 Helsinki, FinlandDepartment of Health Security, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00271 Helsinki, FinlandRisk Assessment Unit, Finnish Food Authority, Mustialankatu 3, 00790 Helsinki, FinlandDepartment of Health Security, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00271 Helsinki, FinlandDepartment of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Agnes Sjöbergin katu 2, 00790 Helsinki, FinlandAtria Plc, Itikanmäenkatu 3, 60100 Seinäjoki, FinlandDepartment of Health Security, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00271 Helsinki, FinlandDepartment of Health Security, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00271 Helsinki, FinlandCampylobacteriosis causes a significant disease burden in humans worldwide and is the most common type of zoonotic gastroenteritis in Finland. To identify infection sources for domestic <i>Campylobacter</i> infections, we analyzed <i>Campylobacter</i> case data from the Finnish Infectious Disease Register (FIDR) in 2004–2021 and outbreak data from the National Food- and Waterborne Outbreak Register (FWO Register) in 2010–2021, and conducted a pilot case-control study (256 cases and 756 controls) with source attribution and patient sample analysis using whole-genome sequencing (WGS) in July–August 2022. In the FIDR, 41% of the cases lacked information on travel history. Based on the case-control study, we estimated that of all cases, 39% were of domestic origin. Using WGS, 22 clusters of two or more cases were observed among 185 domestic cases, none of which were reported to the FWO register. Based on this case-control study and source attribution, poultry is an important source of campylobacteriosis in Finland. More extensive sampling and comparison of patient, food, animal, and environmental isolates is needed to estimate the significance of other sources. In Finland, campylobacteriosis is more often of domestic origin than FIDR notifications indicate. To identify the domestic cases, travel information should be included in the FIDR notification, and to improve outbreak detection, all domestic patient isolates should be sequenced.https://www.mdpi.com/2076-2607/12/1/132<i>Campylobacter</i> infectionsdemographyrisk factorswhole-genome sequencingsource attributionFinland |
| spellingShingle | Kristiina Suominen Tessa Häkkänen Jukka Ranta Jukka Ollgren Rauni Kivistö Päivikki Perko-Mäkelä Saara Salmenlinna Ruska Rimhanen-Finne Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 Microorganisms <i>Campylobacter</i> infections demography risk factors whole-genome sequencing source attribution Finland |
| title | Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 |
| title_full | Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 |
| title_fullStr | Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 |
| title_full_unstemmed | Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 |
| title_short | Campylobacteriosis in Finland: Passive Surveillance in 2004–2021 and a Pilot Case-Control Study with Whole-Genome Sequencing in Summer 2022 |
| title_sort | campylobacteriosis in finland passive surveillance in 2004 2021 and a pilot case control study with whole genome sequencing in summer 2022 |
| topic | <i>Campylobacter</i> infections demography risk factors whole-genome sequencing source attribution Finland |
| url | https://www.mdpi.com/2076-2607/12/1/132 |
| work_keys_str_mv | AT kristiinasuominen campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT tessahakkanen campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT jukkaranta campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT jukkaollgren campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT raunikivisto campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT paivikkiperkomakela campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT saarasalmenlinna campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 AT ruskarimhanenfinne campylobacteriosisinfinlandpassivesurveillancein20042021andapilotcasecontrolstudywithwholegenomesequencinginsummer2022 |