Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level
Abstract Using data from the Korean Genome and Epidemiology Study, we identified weight-change patterns during midlife using a group-based trajectory model, and evaluated their associations with the incidence of cardiovascular disease (CVD). At baseline, there were 8774 CVD-free participants. Group-...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17765-0 |
| _version_ | 1811215370443292672 |
|---|---|
| author | Hye Ah Lee Hyesook Park |
| author_facet | Hye Ah Lee Hyesook Park |
| author_sort | Hye Ah Lee |
| collection | DOAJ |
| description | Abstract Using data from the Korean Genome and Epidemiology Study, we identified weight-change patterns during midlife using a group-based trajectory model, and evaluated their associations with the incidence of cardiovascular disease (CVD). At baseline, there were 8774 CVD-free participants. Group-based modeling was used to analyze patterns of weight change over about 16 years. Using multiple model, we evaluated the association between weight-change patterns and CVD risk. During the follow-up period, 741 new CVD cases were identified. The weight-change patterns were characterized as ‘gradual weight gain’, ‘stable weight’, ‘slight weight loss’, and ‘gradual weight loss’. The association between weight-change patterns and CVD risk differed depending on the level of physical activity (PA) at baseline (p interaction < 0.05). Compared with the stable-weight group, the risk of all CVD (HR 2.5, 95% CI 1.5–4.3) and non-fatal CVD (HR 2.8, 95% CI 1.6–4.9) among the gradual-weight-loss group was apparent in the lowest PA quartile. In addition, on average, a decrease in skeletal-muscle-mass (SMM) levels was observed during the follow-up period, but the decrease in SMM in the gradual-weight-loss group was greater than in the gradual-weight-gain group. Our findings show that gradual weight loss was associated with CVD risk, which was dependent on PA levels. |
| first_indexed | 2024-04-12T06:21:36Z |
| format | Article |
| id | doaj.art-9c42563bd0474b5489c01c643c2910a3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T06:21:36Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9c42563bd0474b5489c01c643c2910a32022-12-22T03:44:17ZengNature PortfolioScientific Reports2045-23222022-08-0112111010.1038/s41598-022-17765-0Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity levelHye Ah Lee0Hyesook Park1Clinical Trial Center, Ewha Womans University Mokdong HospitalDepartment of Preventive Medicine, College of Medicine, Ewha Womans UniversityAbstract Using data from the Korean Genome and Epidemiology Study, we identified weight-change patterns during midlife using a group-based trajectory model, and evaluated their associations with the incidence of cardiovascular disease (CVD). At baseline, there were 8774 CVD-free participants. Group-based modeling was used to analyze patterns of weight change over about 16 years. Using multiple model, we evaluated the association between weight-change patterns and CVD risk. During the follow-up period, 741 new CVD cases were identified. The weight-change patterns were characterized as ‘gradual weight gain’, ‘stable weight’, ‘slight weight loss’, and ‘gradual weight loss’. The association between weight-change patterns and CVD risk differed depending on the level of physical activity (PA) at baseline (p interaction < 0.05). Compared with the stable-weight group, the risk of all CVD (HR 2.5, 95% CI 1.5–4.3) and non-fatal CVD (HR 2.8, 95% CI 1.6–4.9) among the gradual-weight-loss group was apparent in the lowest PA quartile. In addition, on average, a decrease in skeletal-muscle-mass (SMM) levels was observed during the follow-up period, but the decrease in SMM in the gradual-weight-loss group was greater than in the gradual-weight-gain group. Our findings show that gradual weight loss was associated with CVD risk, which was dependent on PA levels.https://doi.org/10.1038/s41598-022-17765-0 |
| spellingShingle | Hye Ah Lee Hyesook Park Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level Scientific Reports |
| title | Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level |
| title_full | Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level |
| title_fullStr | Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level |
| title_full_unstemmed | Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level |
| title_short | Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level |
| title_sort | association between long term weight change trajectory and cardiovascular disease risk by physical activity level |
| url | https://doi.org/10.1038/s41598-022-17765-0 |
| work_keys_str_mv | AT hyeahlee associationbetweenlongtermweightchangetrajectoryandcardiovasculardiseaseriskbyphysicalactivitylevel AT hyesookpark associationbetweenlongtermweightchangetrajectoryandcardiovasculardiseaseriskbyphysicalactivitylevel |