Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis
IntroductionPosttraumatic stress disorder (PTSD) is the most common mental health disorder to develop following exposure to trauma. Studies have reported conflicting results regarding changes in immune biomarkers and alterations in the abundance of bacterial taxa and microbial diversity in patients...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1349883/full |
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| author | Pavlo Petakh Pavlo Petakh Valentyn Oksenych Iryna Kamyshna Iryna Boisak Katerina Lyubomirskaya Oleksandr Kamyshnyi |
| author_facet | Pavlo Petakh Pavlo Petakh Valentyn Oksenych Iryna Kamyshna Iryna Boisak Katerina Lyubomirskaya Oleksandr Kamyshnyi |
| author_sort | Pavlo Petakh |
| collection | DOAJ |
| description | IntroductionPosttraumatic stress disorder (PTSD) is the most common mental health disorder to develop following exposure to trauma. Studies have reported conflicting results regarding changes in immune biomarkers and alterations in the abundance of bacterial taxa and microbial diversity in patients with PTSD.AimThe purpose of this meta-analysis is to summarize existing studies examining gut microbiota characteristics and changes in immune biomarkers in patients with PTSD.MethodsRelevant studies were systematically searched in PubMed, Scopus, and Embase, published in English between January 1, 1960, and December 1, 2023. The outcomes included changes in abundance and diversity in gut microbiota (gut microbiota part) and changes in immune biomarkers (immune part).ResultsThe meta-analysis included a total of 15 studies, with 9 focusing on changes in inflammatory biomarkers and 6 focusing on changes in gut microbiota composition in patients with PTSD. No differences were observed between groups for all inflammatory biomarkers (P≥0.05). Two of the six studies found that people with PTSD had less alpha diversity. However, the overall Standardized Mean Difference (SMD) for the Shannon Diversity Index was not significant (SMD 0.27, 95% CI -0.62–0.609, p = 0.110). Regarding changes in abundance, in two of the studies, a significant decrease in Lachnospiraceae bacteria was observed.ConclusionThis meta-analysis provides a comprehensive overview of gut microbiota characteristics in PTSD, suggesting potential associations with immune dysregulation. Future research should address study limitations, explore causal relationships, and consider additional factors influencing immune function in individuals with PTSD.Systematic review registrationhttps://www.crd.york.ac.uk, identifier CRD42023476590. |
| first_indexed | 2024-03-08T03:18:50Z |
| format | Article |
| id | doaj.art-9c4345d5f44c4006b272af80b62e1a95 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T03:18:50Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9c4345d5f44c4006b272af80b62e1a952024-02-12T13:27:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13498831349883Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysisPavlo Petakh0Pavlo Petakh1Valentyn Oksenych2Iryna Kamyshna3Iryna Boisak4Katerina Lyubomirskaya5Oleksandr Kamyshnyi6Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, UkraineDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineBroegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Childhood Diseases, Uzhhorod National University, Uzhhorod, UkraineDepartment of Obstetrics and Gynecology, Zaporizhzhia State Medical and Pharmaceuticals University, Zaporizhzhia, UkraineDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineIntroductionPosttraumatic stress disorder (PTSD) is the most common mental health disorder to develop following exposure to trauma. Studies have reported conflicting results regarding changes in immune biomarkers and alterations in the abundance of bacterial taxa and microbial diversity in patients with PTSD.AimThe purpose of this meta-analysis is to summarize existing studies examining gut microbiota characteristics and changes in immune biomarkers in patients with PTSD.MethodsRelevant studies were systematically searched in PubMed, Scopus, and Embase, published in English between January 1, 1960, and December 1, 2023. The outcomes included changes in abundance and diversity in gut microbiota (gut microbiota part) and changes in immune biomarkers (immune part).ResultsThe meta-analysis included a total of 15 studies, with 9 focusing on changes in inflammatory biomarkers and 6 focusing on changes in gut microbiota composition in patients with PTSD. No differences were observed between groups for all inflammatory biomarkers (P≥0.05). Two of the six studies found that people with PTSD had less alpha diversity. However, the overall Standardized Mean Difference (SMD) for the Shannon Diversity Index was not significant (SMD 0.27, 95% CI -0.62–0.609, p = 0.110). Regarding changes in abundance, in two of the studies, a significant decrease in Lachnospiraceae bacteria was observed.ConclusionThis meta-analysis provides a comprehensive overview of gut microbiota characteristics in PTSD, suggesting potential associations with immune dysregulation. Future research should address study limitations, explore causal relationships, and consider additional factors influencing immune function in individuals with PTSD.Systematic review registrationhttps://www.crd.york.ac.uk, identifier CRD42023476590.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1349883/fullgut microbiomestresspost-traumatic stress disorderinflammationIL-6Lachnospiraceae |
| spellingShingle | Pavlo Petakh Pavlo Petakh Valentyn Oksenych Iryna Kamyshna Iryna Boisak Katerina Lyubomirskaya Oleksandr Kamyshnyi Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis Frontiers in Immunology gut microbiome stress post-traumatic stress disorder inflammation IL-6 Lachnospiraceae |
| title | Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis |
| title_full | Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis |
| title_fullStr | Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis |
| title_full_unstemmed | Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis |
| title_short | Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis |
| title_sort | exploring the interplay between posttraumatic stress disorder gut microbiota and inflammatory biomarkers a comprehensive meta analysis |
| topic | gut microbiome stress post-traumatic stress disorder inflammation IL-6 Lachnospiraceae |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1349883/full |
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