Effect of Vitamin D on Anginal Episodes in Vitamin D Deficient Patients with Chronic Stable Angina on Medical Management
Introduction: Vitamin D deficiency has been found to contribute to various cardiac conditions, such as hypertension, coronary artery disease, stroke, and atherosclerosis. However, the clinical cardiovascular benefits after short term supplementation have not been reported. Aim: To study the ben...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8345/20521_CE[Ra1]_F(GH)_PF1(EKAK)_PFA(AK).pdf |
| Summary: | Introduction: Vitamin D deficiency has been found to contribute
to various cardiac conditions, such as hypertension, coronary
artery disease, stroke, and atherosclerosis. However, the clinical
cardiovascular benefits after short term supplementation have
not been reported.
Aim: To study the beneficial effect of Vitamin D supplementation
on angina episodes in Vitamin D deficient patients with chronic
stable angina on medical management.
Materials and Methods: A total of 40 patients were studied with
group 1 (20 patients) with low Vitamin D levels and group 2 with
normal Vitamin D levels. 60000 IU of Vitamin D supplementation
was given every week for 8 weeks in group 1. Frequency of
anginal episodes and use of sub-lingual nitrates were compared
at base-line and after 8 weeks post supplementation.
Results: Significant 20% (p <0.05) reduction in anginal episodes
and 17.24% (p <0.05) reduction in use of sub-lingual nitrates
was noted in group1 after Vitamin D supplementation. The
benefits were independent of BP, heart rate and medications,
thus, attributing to supplementation. No significant change was
noted in group 2.
Conclusion: Cardiovascular patients need to be evaluated for
Vitamin D deficiency. Supplementation to correct Vitamin D
levels may have additional cardiovascular benefits like reduction
in angina episodes. |
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| ISSN: | 2249-782X 0973-709X |