CTL escape and viral fitness in HIV/SIV infection
Cytotoxic T lymphocyte (CTL) responses exert a suppressive effect on HIV and simian immunodeficiency virus (SIV) replication. Under the CTL pressure, viral CTL escape mutations are frequently selected for with viral fitness costs. Viruses with such CTL escape mutations often need additional viral ge...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00267/full |
| _version_ | 1819086183054966784 |
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| author | Sayuri eSeki Sayuri eSeki Tetsuro eMatano Tetsuro eMatano |
| author_facet | Sayuri eSeki Sayuri eSeki Tetsuro eMatano Tetsuro eMatano |
| author_sort | Sayuri eSeki |
| collection | DOAJ |
| description | Cytotoxic T lymphocyte (CTL) responses exert a suppressive effect on HIV and simian immunodeficiency virus (SIV) replication. Under the CTL pressure, viral CTL escape mutations are frequently selected for with viral fitness costs. Viruses with such CTL escape mutations often need additional viral genome mutations for recovery of viral fitness. Persistent HIV/SIV infection sometimes shows replacement of a CTL escape mutation with an alternative escape mutation toward higher viral fitness. Thus, multiple viral genome changes under CTL pressure are observed in the chronic phase of HIV/SIV infection. HIV/SIV transmission to HLA/MHC-mismatched hosts drives further viral genome changes including additional CTL escape mutations and reversions under different CTL pressure. Understanding of viral structure/function and host CTL responses would contribute to prediction of HIV evolution and control of HIV prevalence. |
| first_indexed | 2024-12-21T21:16:12Z |
| format | Article |
| id | doaj.art-9c4495244c3f4e3e8a0937f6c5071143 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T21:16:12Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9c4495244c3f4e3e8a0937f6c50711432022-12-21T18:50:00ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-01-01210.3389/fmicb.2011.0026718512CTL escape and viral fitness in HIV/SIV infectionSayuri eSeki0Sayuri eSeki1Tetsuro eMatano2Tetsuro eMatano3National Institute of Infectious DiseasesThe Institute of Medical Science, The University of TokyoNational Institute of Infectious DiseasesThe Institute of Medical Science, The University of TokyoCytotoxic T lymphocyte (CTL) responses exert a suppressive effect on HIV and simian immunodeficiency virus (SIV) replication. Under the CTL pressure, viral CTL escape mutations are frequently selected for with viral fitness costs. Viruses with such CTL escape mutations often need additional viral genome mutations for recovery of viral fitness. Persistent HIV/SIV infection sometimes shows replacement of a CTL escape mutation with an alternative escape mutation toward higher viral fitness. Thus, multiple viral genome changes under CTL pressure are observed in the chronic phase of HIV/SIV infection. HIV/SIV transmission to HLA/MHC-mismatched hosts drives further viral genome changes including additional CTL escape mutations and reversions under different CTL pressure. Understanding of viral structure/function and host CTL responses would contribute to prediction of HIV evolution and control of HIV prevalence.http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00267/fullCapsidHIVcytotoxic T lymphocyteMHCSIVescape mutation |
| spellingShingle | Sayuri eSeki Sayuri eSeki Tetsuro eMatano Tetsuro eMatano CTL escape and viral fitness in HIV/SIV infection Frontiers in Microbiology Capsid HIV cytotoxic T lymphocyte MHC SIV escape mutation |
| title | CTL escape and viral fitness in HIV/SIV infection |
| title_full | CTL escape and viral fitness in HIV/SIV infection |
| title_fullStr | CTL escape and viral fitness in HIV/SIV infection |
| title_full_unstemmed | CTL escape and viral fitness in HIV/SIV infection |
| title_short | CTL escape and viral fitness in HIV/SIV infection |
| title_sort | ctl escape and viral fitness in hiv siv infection |
| topic | Capsid HIV cytotoxic T lymphocyte MHC SIV escape mutation |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00267/full |
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