Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle

Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle

Quinazoline-based α1,-adrenoceptor antagonists, in particular doxazosin, terazosin, are suggested to display antineoplastic activity against prostate cancers. However, there are few studies elucidating the effect of prazosin. In this study, prazosin displayed antiproliferative activity superior to t...

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Bibliographic Details
Main Authors: Ssu-Chia Lin, Shih-Chieh Chueht, Che-Jen Hsiao, Tsia-Kun Li, Tzu-Hsuan Chen, Cho-Hwa Liao, Ping-Chiang Lyu, Jih-Hwa Guh
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Prazosin
DNA damage
cell cycle
Cdc25c
mitochondriainvolved apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800637

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