U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study
Abstract Background Phenotypic age acceleration, which reflects the difference between phenotypic age and chronological age, is an assessment to measure accelerated aging. Klotho is a protein related to slower aging, but its association with accelerated aging remains unclear. Methods Based on data f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04479-9 |
| _version_ | 1827602859265359872 |
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| author | Heng Li Shuai Miao Min Zhang Peng Zhang Yan-Bin Li Rui-Sheng Duan |
| author_facet | Heng Li Shuai Miao Min Zhang Peng Zhang Yan-Bin Li Rui-Sheng Duan |
| author_sort | Heng Li |
| collection | DOAJ |
| description | Abstract Background Phenotypic age acceleration, which reflects the difference between phenotypic age and chronological age, is an assessment to measure accelerated aging. Klotho is a protein related to slower aging, but its association with accelerated aging remains unclear. Methods Based on data from the 2007–2010 National Health and Nutrition Examination Survey, phenotypic age was calculated using chronological age and 9 aging-related biomarkers. A total of 4388 participants aged 40 to 79 years with measured serum Klotho and calculated phenotypic age were enrolled. The association between serum Klotho and phenotypic age acceleration was estimated using multivariable linear regression models. The possible nonlinear relationship was examined with smooth curve fitting. We also conducted a segmented regression model to examine the threshold effect. Results The association between serum Klotho and phenotypic age acceleration followed a U-shaped curve (p for nonlinearity < 0.001), with the inflection point at 870.7 pg/ml. The phenotypic age acceleration significantly decreased with the increment of serum Klotho (per SD increment: β -1.77; 95% CI, -2.57 ~ -0.98) in participants with serum Klotho < 870.7 pg/ml, and increased with the increment of serum Klotho (per SD increment:β, 1.03; 95% CI: 0.53 ~ 1.54) in participants with serum Klotho ≥ 870.7 pg/ml. Conclusion There was a U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population. |
| first_indexed | 2024-03-09T05:27:34Z |
| format | Article |
| id | doaj.art-9c4a34a66e0e4bad8f085a9a03964f95 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-09T05:27:34Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-9c4a34a66e0e4bad8f085a9a03964f952023-12-03T12:35:39ZengBMCBMC Geriatrics1471-23182023-11-0123111010.1186/s12877-023-04479-9U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional studyHeng Li0Shuai Miao1Min Zhang2Peng Zhang3Yan-Bin Li4Rui-Sheng Duan5Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalMedical School of Chinese People’s Liberation Army (PLA)Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalAbstract Background Phenotypic age acceleration, which reflects the difference between phenotypic age and chronological age, is an assessment to measure accelerated aging. Klotho is a protein related to slower aging, but its association with accelerated aging remains unclear. Methods Based on data from the 2007–2010 National Health and Nutrition Examination Survey, phenotypic age was calculated using chronological age and 9 aging-related biomarkers. A total of 4388 participants aged 40 to 79 years with measured serum Klotho and calculated phenotypic age were enrolled. The association between serum Klotho and phenotypic age acceleration was estimated using multivariable linear regression models. The possible nonlinear relationship was examined with smooth curve fitting. We also conducted a segmented regression model to examine the threshold effect. Results The association between serum Klotho and phenotypic age acceleration followed a U-shaped curve (p for nonlinearity < 0.001), with the inflection point at 870.7 pg/ml. The phenotypic age acceleration significantly decreased with the increment of serum Klotho (per SD increment: β -1.77; 95% CI, -2.57 ~ -0.98) in participants with serum Klotho < 870.7 pg/ml, and increased with the increment of serum Klotho (per SD increment:β, 1.03; 95% CI: 0.53 ~ 1.54) in participants with serum Klotho ≥ 870.7 pg/ml. Conclusion There was a U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population.https://doi.org/10.1186/s12877-023-04479-9KlothoPhenotypic ageAccelerated agingU-shapedNHANES |
| spellingShingle | Heng Li Shuai Miao Min Zhang Peng Zhang Yan-Bin Li Rui-Sheng Duan U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study BMC Geriatrics Klotho Phenotypic age Accelerated aging U-shaped NHANES |
| title | U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study |
| title_full | U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study |
| title_fullStr | U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study |
| title_full_unstemmed | U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study |
| title_short | U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study |
| title_sort | u shaped association between serum klotho and accelerated aging among the middle aged and elderly us population a cross sectional study |
| topic | Klotho Phenotypic age Accelerated aging U-shaped NHANES |
| url | https://doi.org/10.1186/s12877-023-04479-9 |
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