Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses
The alterations in gut bacteria are closely related to colorectal cancer. However, studies on adenoma are still scarce. Besides, the associations of gut viruses with colorectal tumor, and the interactions of bacteria with viruses in colorectal tumors are still under exploration. Therefore, a metagen...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/19/4662 |
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| author | Jia Zhang Yangting He Lu Xia Jing Yi Zhen Wang Yingying Zhao Xuemei Song Jia Li Hongli Liu Xinjun Liang Shaofa Nie Li Liu |
| author_facet | Jia Zhang Yangting He Lu Xia Jing Yi Zhen Wang Yingying Zhao Xuemei Song Jia Li Hongli Liu Xinjun Liang Shaofa Nie Li Liu |
| author_sort | Jia Zhang |
| collection | DOAJ |
| description | The alterations in gut bacteria are closely related to colorectal cancer. However, studies on adenoma are still scarce. Besides, the associations of gut viruses with colorectal tumor, and the interactions of bacteria with viruses in colorectal tumors are still under exploration. Therefore, a metagenomic sequencing of stool samples from patients with colorectal adenoma (CRA), colorectal cancer (CRC), and healthy controls was performed to identify changes in gut microbiome in patients with colorectal tumors. Five CRC-enriched bacteria (<i>Peptostreptococcus stomatis</i>, <i>Clostridium symbiosum</i>, <i>Hungatella hathewayi</i>, <i>Parvimonas micra</i>, and <i>Gemella morbillorum</i>) were identified as a diagnostic model to identify CRC patients, and the efficacy of the diagnostic model was verifiable in 1523 metagenomic samples from ten cohorts of eight different countries. We identified the positive association of <i>Bacteroides fragilis</i> with PD-L1 expression and PD-1 checkpoint pathway, providing a possible direction for studying bacterial carcinogenesis mechanisms. Furthermore, the increased interactions within the microbiome in patients may play roles in the development of CRC. In conclusion, this study identified novel microbiota combinations with discrimination for colorectal tumor, and revealed the potential interactions of gut bacteria with viruses in the adenoma-carcinoma sequence, which implies that the microbiome, but not only bacteria, should be paid more attention in further studies. |
| first_indexed | 2024-03-09T21:57:53Z |
| format | Article |
| id | doaj.art-9c4adcf8d42e42cbbbc31912aeec64a5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:57:53Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9c4adcf8d42e42cbbbc31912aeec64a52023-11-23T19:54:30ZengMDPI AGCancers2072-66942022-09-011419466210.3390/cancers14194662Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and VirusesJia Zhang0Yangting He1Lu Xia2Jing Yi3Zhen Wang4Yingying Zhao5Xuemei Song6Jia Li7Hongli Liu8Xinjun Liang9Shaofa Nie10Li Liu11Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, ChinaDepartment of Medical Oncology, Tongji Medical College, Hubei Cancer Hospital, Huazhong University of Science and Technology, Wuhan 430079, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaThe alterations in gut bacteria are closely related to colorectal cancer. However, studies on adenoma are still scarce. Besides, the associations of gut viruses with colorectal tumor, and the interactions of bacteria with viruses in colorectal tumors are still under exploration. Therefore, a metagenomic sequencing of stool samples from patients with colorectal adenoma (CRA), colorectal cancer (CRC), and healthy controls was performed to identify changes in gut microbiome in patients with colorectal tumors. Five CRC-enriched bacteria (<i>Peptostreptococcus stomatis</i>, <i>Clostridium symbiosum</i>, <i>Hungatella hathewayi</i>, <i>Parvimonas micra</i>, and <i>Gemella morbillorum</i>) were identified as a diagnostic model to identify CRC patients, and the efficacy of the diagnostic model was verifiable in 1523 metagenomic samples from ten cohorts of eight different countries. We identified the positive association of <i>Bacteroides fragilis</i> with PD-L1 expression and PD-1 checkpoint pathway, providing a possible direction for studying bacterial carcinogenesis mechanisms. Furthermore, the increased interactions within the microbiome in patients may play roles in the development of CRC. In conclusion, this study identified novel microbiota combinations with discrimination for colorectal tumor, and revealed the potential interactions of gut bacteria with viruses in the adenoma-carcinoma sequence, which implies that the microbiome, but not only bacteria, should be paid more attention in further studies.https://www.mdpi.com/2072-6694/14/19/4662colorectal cancergut microbiomediagnostic modelbacteriavirus |
| spellingShingle | Jia Zhang Yangting He Lu Xia Jing Yi Zhen Wang Yingying Zhao Xuemei Song Jia Li Hongli Liu Xinjun Liang Shaofa Nie Li Liu Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses Cancers colorectal cancer gut microbiome diagnostic model bacteria virus |
| title | Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses |
| title_full | Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses |
| title_fullStr | Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses |
| title_full_unstemmed | Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses |
| title_short | Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses |
| title_sort | expansion of colorectal cancer biomarkers based on gut bacteria and viruses |
| topic | colorectal cancer gut microbiome diagnostic model bacteria virus |
| url | https://www.mdpi.com/2072-6694/14/19/4662 |
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