Failure of immunosurveillance accelerates aging
Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumula...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-04-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2019.1575117 |
| _version_ | 1818573483885461504 |
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| author | Maria Perez-Lanzon Laurence Zitvogel Guido Kroemer |
| author_facet | Maria Perez-Lanzon Laurence Zitvogel Guido Kroemer |
| author_sort | Maria Perez-Lanzon |
| collection | DOAJ |
| description | Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected. |
| first_indexed | 2024-12-15T00:11:56Z |
| format | Article |
| id | doaj.art-9c52429e323541519e32d96a0b92da50 |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-15T00:11:56Z |
| publishDate | 2019-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-9c52429e323541519e32d96a0b92da502022-12-21T22:42:34ZengTaylor & Francis GroupOncoImmunology2162-402X2019-04-018410.1080/2162402X.2019.15751171575117Failure of immunosurveillance accelerates agingMaria Perez-Lanzon0Laurence Zitvogel1Guido Kroemer2Centre de Recherche des CordeliersParis Sud/Paris XI UniversityCentre de Recherche des CordeliersImmunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.http://dx.doi.org/10.1080/2162402X.2019.1575117age-related diseasecytotoxic t cellsnk cellsimmunosenescencesenescence |
| spellingShingle | Maria Perez-Lanzon Laurence Zitvogel Guido Kroemer Failure of immunosurveillance accelerates aging OncoImmunology age-related disease cytotoxic t cells nk cells immunosenescence senescence |
| title | Failure of immunosurveillance accelerates aging |
| title_full | Failure of immunosurveillance accelerates aging |
| title_fullStr | Failure of immunosurveillance accelerates aging |
| title_full_unstemmed | Failure of immunosurveillance accelerates aging |
| title_short | Failure of immunosurveillance accelerates aging |
| title_sort | failure of immunosurveillance accelerates aging |
| topic | age-related disease cytotoxic t cells nk cells immunosenescence senescence |
| url | http://dx.doi.org/10.1080/2162402X.2019.1575117 |
| work_keys_str_mv | AT mariaperezlanzon failureofimmunosurveillanceacceleratesaging AT laurencezitvogel failureofimmunosurveillanceacceleratesaging AT guidokroemer failureofimmunosurveillanceacceleratesaging |