Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy
Objective: Infections are an important cause of morbidity and mortality after hysterectomy. Here, we aimed to investigate and evaluate the beneficial effects of metronidazole vaginal gel on the rate of surgical site infections in women undergoing elective abdominal hysterectomy. Methods: This is a r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Research in Pharmacy Practice |
| Subjects: | |
| Online Access: | http://www.jrpp.net/article.asp?issn=2319-9644;year=2023;volume=12;issue=1;spage=9;epage=14;aulast=Sabet |
| _version_ | 1797231758873198592 |
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| author | Fahimeh Sabet Sara Ravan Azar Danesh Shahraki |
| author_facet | Fahimeh Sabet Sara Ravan Azar Danesh Shahraki |
| author_sort | Fahimeh Sabet |
| collection | DOAJ |
| description | Objective: Infections are an important cause of morbidity and mortality after hysterectomy. Here, we aimed to investigate and evaluate the beneficial effects of metronidazole vaginal gel on the rate of surgical site infections in women undergoing elective abdominal hysterectomy. Methods: This is a randomized prospective, double-blind controlled clinical trial performed in 2020 in Isfahan on 108 candidates for elective hysterectomy. At the beginning of the study, we completed a checklist of the patient's characteristics (patient age, body mass index [BMI], and history of medical conditions such as diabetes, hypertension, anemia, and immune deficiency) and the cause of hysterectomy. All patients were randomized into two groups. The first group received a lubricant vaginal gel single dosage, and the second group received a 0.75% metronidazole vaginal gel single dosage the night before surgery. Patients were visited up to 6 weeks after surgery, and the frequency of infection at the surgical site was determined. Findings: The rates of infection were lower in patients who received metronidazole vaginal gel (5.8%) compared to the control group (11.6%) (P = 0.03). Patients with an estimated blood loss volume of more than 500 mL had higher rates of infection (13.46%) compared to patients with a bleeding volume of fewer than 500 mL (1.9%) (P = 0.001). We also found that patients with diabetes (13.5%) and patients with BMI more than 30 kg/m2 (13.5%) had higher rates of infection compared to patients without diabetes (5.8%) and patients with BMI <30 kg/m2 (11.5%) (P = 0.001 for both). Patients with higher hospitalization duration had higher infection rates (P = 0.009). Conclusion: Administration of a single dosage of metronidazole vaginal gel before abdominal hysterectomy may reduce surgical site infection and have clinical values. |
| first_indexed | 2024-04-24T15:49:29Z |
| format | Article |
| id | doaj.art-9c5248664c234c7095869adbd99cd6fa |
| institution | Directory Open Access Journal |
| issn | 2319-9644 2279-042X |
| language | English |
| last_indexed | 2024-04-24T15:49:29Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Pharmacy Practice |
| spelling | doaj.art-9c5248664c234c7095869adbd99cd6fa2024-04-01T12:54:22ZengWolters Kluwer Medknow PublicationsJournal of Research in Pharmacy Practice2319-96442279-042X2023-01-0112191410.4103/jrpp.jrpp_66_21Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomyFahimeh SabetSara RavanAzar Danesh ShahrakiObjective: Infections are an important cause of morbidity and mortality after hysterectomy. Here, we aimed to investigate and evaluate the beneficial effects of metronidazole vaginal gel on the rate of surgical site infections in women undergoing elective abdominal hysterectomy. Methods: This is a randomized prospective, double-blind controlled clinical trial performed in 2020 in Isfahan on 108 candidates for elective hysterectomy. At the beginning of the study, we completed a checklist of the patient's characteristics (patient age, body mass index [BMI], and history of medical conditions such as diabetes, hypertension, anemia, and immune deficiency) and the cause of hysterectomy. All patients were randomized into two groups. The first group received a lubricant vaginal gel single dosage, and the second group received a 0.75% metronidazole vaginal gel single dosage the night before surgery. Patients were visited up to 6 weeks after surgery, and the frequency of infection at the surgical site was determined. Findings: The rates of infection were lower in patients who received metronidazole vaginal gel (5.8%) compared to the control group (11.6%) (P = 0.03). Patients with an estimated blood loss volume of more than 500 mL had higher rates of infection (13.46%) compared to patients with a bleeding volume of fewer than 500 mL (1.9%) (P = 0.001). We also found that patients with diabetes (13.5%) and patients with BMI more than 30 kg/m2 (13.5%) had higher rates of infection compared to patients without diabetes (5.8%) and patients with BMI <30 kg/m2 (11.5%) (P = 0.001 for both). Patients with higher hospitalization duration had higher infection rates (P = 0.009). Conclusion: Administration of a single dosage of metronidazole vaginal gel before abdominal hysterectomy may reduce surgical site infection and have clinical values.http://www.jrpp.net/article.asp?issn=2319-9644;year=2023;volume=12;issue=1;spage=9;epage=14;aulast=Sabethysterectomyinfectionmetronidazoleprophylaxis |
| spellingShingle | Fahimeh Sabet Sara Ravan Azar Danesh Shahraki Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy Journal of Research in Pharmacy Practice hysterectomy infection metronidazole prophylaxis |
| title | Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| title_full | Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| title_fullStr | Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| title_full_unstemmed | Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| title_short | Prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| title_sort | prophylaxis effect of metronidazole vaginal gel in decreasing the risk of surgical site infections after elective hysterectomy |
| topic | hysterectomy infection metronidazole prophylaxis |
| url | http://www.jrpp.net/article.asp?issn=2319-9644;year=2023;volume=12;issue=1;spage=9;epage=14;aulast=Sabet |
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