Microdialysis Determination of Cefquinome Pharmacokinetics in Murine Thigh From Healthy, Neutropenic, and Actinobacillus pleuropneumoniae-Infected Mice

Microdialysis Determination of Cefquinome Pharmacokinetics in Murine Thigh From Healthy, Neutropenic, and Actinobacillus pleuropneumoniae-Infected Mice

This study was aimed at applying microdialysis to explore cefquinome pharmacokinetics in thigh and plasma of healthy, neutropenic, and Actinobacillus pleuropneumoniae-infected mice. The relative recoveries (RRs) were tested in vitro by dialysis and retrodialysis and in vivo by retrodialysis. ICR mic...

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Bibliographic Details
Main Authors: Longfei Zhang, Lihua Yao, Zheng Kang, Zilong Huang, Xiaoyan Gu, Xiangguang Shen, Huanzhong Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
cefquinome
microdialysis
pharmacokinetics
in vivo
dialysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00249/full

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