From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution
Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/13/2/61 |
| _version_ | 1797485844039204864 |
|---|---|
| author | Daniela Trindade Nuno Alves Carla Moura |
| author_facet | Daniela Trindade Nuno Alves Carla Moura |
| author_sort | Daniela Trindade |
| collection | DOAJ |
| description | Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc. |
| first_indexed | 2024-03-09T23:25:33Z |
| format | Article |
| id | doaj.art-9c55c2dc6ef54161a67dd90cebd29703 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T23:25:33Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-9c55c2dc6ef54161a67dd90cebd297032023-11-23T17:19:32ZengMDPI AGJournal of Functional Biomaterials2079-49832022-05-011326110.3390/jfb13020061From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc SubstitutionDaniela Trindade0Nuno Alves1Carla Moura2Centre for Rapid and Sustainable Product Development (CDRSP), Polytechnic of Leiria, 2430-028 Marinha Grande, PortugalCentre for Rapid and Sustainable Product Development (CDRSP), Polytechnic of Leiria, 2430-028 Marinha Grande, PortugalCentre for Rapid and Sustainable Product Development (CDRSP), Polytechnic of Leiria, 2430-028 Marinha Grande, PortugalCurrent treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc.https://www.mdpi.com/2079-4983/13/2/61temporomandibular discdecellularizationextracellular matrix |
| spellingShingle | Daniela Trindade Nuno Alves Carla Moura From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution Journal of Functional Biomaterials temporomandibular disc decellularization extracellular matrix |
| title | From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution |
| title_full | From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution |
| title_fullStr | From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution |
| title_full_unstemmed | From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution |
| title_short | From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution |
| title_sort | from animal to human re using acellular extracellular matrices for temporomandibular disc substitution |
| topic | temporomandibular disc decellularization extracellular matrix |
| url | https://www.mdpi.com/2079-4983/13/2/61 |
| work_keys_str_mv | AT danielatrindade fromanimaltohumanreusingacellularextracellularmatricesfortemporomandibulardiscsubstitution AT nunoalves fromanimaltohumanreusingacellularextracellularmatricesfortemporomandibulardiscsubstitution AT carlamoura fromanimaltohumanreusingacellularextracellularmatricesfortemporomandibulardiscsubstitution |