Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites

Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites

Diverse ligands of the muscle nicotinic acetylcholine receptor (nAChR) are used as muscle relaxants during surgery. Although a plethora of such molecules exists in the market, there is still a need for new drugs with rapid on/off-set, increased selectivity, and so forth. We found that pyrroloiminoqu...

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Bibliographic Details
Main Authors: Denis S. Kudryavtsev, Ekaterina N. Spirova, Irina V. Shelukhina, Lina V. Son, Yana V. Makarova, Natalia K. Utkina, Igor E. Kasheverov, Victor I. Tsetlin
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Marine Drugs
Subjects:
marine natural products
nicotinic receptors
slow-channel
myasthenic
Online Access:http://www.mdpi.com/1660-3397/16/4/109

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