VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients
Symptoms of essential tremor (ET) are similar to those of Parkinson’s disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the change...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00247/full |
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| author | Ching-Hung eLin Ching-Hung eLin Ching-Hung eLin Chun-Ming eChen Ming-Kuei eLu Ming-Kuei eLu Chon-Haw eTsai Chon-Haw eTsai Jin-Chern eChiou Jin-Chern eChiou Jan-Ray eLiao Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann |
| author_facet | Ching-Hung eLin Ching-Hung eLin Ching-Hung eLin Chun-Ming eChen Ming-Kuei eLu Ming-Kuei eLu Chon-Haw eTsai Chon-Haw eTsai Jin-Chern eChiou Jin-Chern eChiou Jan-Ray eLiao Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann |
| author_sort | Ching-Hung eLin |
| collection | DOAJ |
| description | Symptoms of essential tremor (ET) are similar to those of Parkinson’s disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the changes in brain volume and assessed the compensatory effects of a change in the parts of the brain associated with PD and with ET. To determine the compensatory and/or degenerative anatomical changes in the brains of PD and ET patients, the present study tested, via two VBM approaches (Basic vs. Dartel VBM processing), the anatomical brain images of 10 PD and 10 ET patients, as well as of 13 age-matched normal controls, obtained through a 3T magnetic resonance scanner. These findings indicate that PD and ET caused specific patterns of brain volume alterations in the brains examined. In addition, our observations also revealed compensatory effects, or self-reorganization, occurring in the thalamus and the MTG in the PD and ET patients, due perhaps in part to the enhanced thalamocortical sensorimotor interaction and the head-eye position readjustment, respectively, in these PD and ET patients. Such a distinction may lend itself to use as a biomarker for differentiating between these two diseases. |
| first_indexed | 2024-12-10T16:22:56Z |
| format | Article |
| id | doaj.art-9c571ab8a7da4b83b58f154a2622619c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T16:22:56Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-9c571ab8a7da4b83b58f154a2622619c2022-12-22T01:41:45ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-06-01710.3389/fnhum.2013.0024746476VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor PatientsChing-Hung eLin0Ching-Hung eLin1Ching-Hung eLin2Chun-Ming eChen3Ming-Kuei eLu4Ming-Kuei eLu5Chon-Haw eTsai6Chon-Haw eTsai7Jin-Chern eChiou8Jin-Chern eChiou9Jan-Ray eLiao10Jeng-Ren eDuann11Jeng-Ren eDuann12Jeng-Ren eDuann13Jeng-Ren eDuann14Biomedical Engineering R&D Center, China Medical UniversityBiomedical Electronics Translational Research Center, National Chiao Tung UniversityDepartment of Psychology, Soochow UniversityDepartment of Electrical Engineering, National Chung Hsing UniversityBiomedical Electronics Translational Research Center, National Chiao Tung UniversitySection of Neurology, Department of Medicine, China Medical University HospitalBiomedical Electronics Translational Research Center, National Chiao Tung UniversitySection of Neurology, Department of Medicine, China Medical University HospitalBiomedical Electronics Translational Research Center, National Chiao Tung UniversityBiomedical Engineering R&D Center, China Medical UniversityDepartment of Electrical Engineering, National Chung Hsing UniversityChina Medical UniversityBiomedical Electronics Translational Research Center, National Chiao Tung UniversityBiomedical Engineering R&D Center, China Medical UniversityInstitute for Neural Computation, University of California San DiegoSymptoms of essential tremor (ET) are similar to those of Parkinson’s disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the changes in brain volume and assessed the compensatory effects of a change in the parts of the brain associated with PD and with ET. To determine the compensatory and/or degenerative anatomical changes in the brains of PD and ET patients, the present study tested, via two VBM approaches (Basic vs. Dartel VBM processing), the anatomical brain images of 10 PD and 10 ET patients, as well as of 13 age-matched normal controls, obtained through a 3T magnetic resonance scanner. These findings indicate that PD and ET caused specific patterns of brain volume alterations in the brains examined. In addition, our observations also revealed compensatory effects, or self-reorganization, occurring in the thalamus and the MTG in the PD and ET patients, due perhaps in part to the enhanced thalamocortical sensorimotor interaction and the head-eye position readjustment, respectively, in these PD and ET patients. Such a distinction may lend itself to use as a biomarker for differentiating between these two diseases.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00247/fullBasal GangliaCerebellumEssential Tremorvoxel-based morphometryParkinson’s diseaseMiddle temporal gyrus |
| spellingShingle | Ching-Hung eLin Ching-Hung eLin Ching-Hung eLin Chun-Ming eChen Ming-Kuei eLu Ming-Kuei eLu Chon-Haw eTsai Chon-Haw eTsai Jin-Chern eChiou Jin-Chern eChiou Jan-Ray eLiao Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann Jeng-Ren eDuann VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients Frontiers in Human Neuroscience Basal Ganglia Cerebellum Essential Tremor voxel-based morphometry Parkinson’s disease Middle temporal gyrus |
| title | VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients |
| title_full | VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients |
| title_fullStr | VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients |
| title_full_unstemmed | VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients |
| title_short | VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients |
| title_sort | vbm reveals brain volume differences between parkinson s disease and essential tremor patients |
| topic | Basal Ganglia Cerebellum Essential Tremor voxel-based morphometry Parkinson’s disease Middle temporal gyrus |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00247/full |
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