Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis
Abstract Background Although many studies have explored the correlation between quality of life and survival, none have reported this relationship for specific cancers assessed at distinct time points. This meta-analysis aimed to investigate the impact of pretreatment Global Quality of Life (QOL) an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12267-w |
| _version_ | 1797199411623755776 |
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| author | Taro Okayama Katsuyoshi Suzuki Shinichiro Morishita Junichiro Inoue Takashi Tanaka Jiro Nakano Takuya Fukushima |
| author_facet | Taro Okayama Katsuyoshi Suzuki Shinichiro Morishita Junichiro Inoue Takashi Tanaka Jiro Nakano Takuya Fukushima |
| author_sort | Taro Okayama |
| collection | DOAJ |
| description | Abstract Background Although many studies have explored the correlation between quality of life and survival, none have reported this relationship for specific cancers assessed at distinct time points. This meta-analysis aimed to investigate the impact of pretreatment Global Quality of Life (QOL) and functioning QOL, including physical, social, role, emotional, and cognitive QOLs, on mortality risk in patients with lung cancer. Methods A literature search was conducted across the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and PubMed databases for articles published between their inception and December 2022. Subsequently, 11 studies were selected based on predefined eligibility criteria to investigate the relationship between pretreatment QOLs and mortality risk in patients with lung cancer. Results Pretreatment global, physical, social, role, and emotional QOLs were significantly associated with mortality risk as follows: Global QOL (hazard ratio [HR] = 1.08 95% confidence interval [CI] = 1.03–1.13); Physical QOL (HR = 1.04 95% CI = 1.02–1.05); Social QOL (HR = 1.02 95% CI = 1.01–1.03; Role QOL (HR = 1.01 95% CI = 1.01–1.02); Emotional QOL (HR = 1.01 95% CI = 1.00–1.03). Conclusions These findings underscore the importance of early QOL assessment after diagnosis as well as early provision of physical, social, and psychological support accommodating each patient’s demands. Trial registration The International Prospective Register of Systematic Reviews registration number CRD42023398206, Registered on February 20, 2023. |
| first_indexed | 2024-04-24T07:15:20Z |
| format | Article |
| id | doaj.art-9c581b0a76d84c47a0b4c32a25306350 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T07:15:20Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9c581b0a76d84c47a0b4c32a253063502024-04-21T11:21:42ZengBMCBMC Cancer1471-24072024-04-0124111110.1186/s12885-024-12267-wPretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysisTaro Okayama0Katsuyoshi Suzuki1Shinichiro Morishita2Junichiro Inoue3Takashi Tanaka4Jiro Nakano5Takuya Fukushima6Division of Rehabilitation Medicine, Shizuoka Cancer CenterDivision of Rehabilitation Medicine, Shizuoka Cancer CenterDepartment of Physical Therapy, School of Health Science, Fukushima Medical UniversityDivision of Rehabilitation Medicine, Kobe University Hospital International Clinical Cancer Research CenterDepartment of Rehabilitation, Hyogo Medical University HospitalFaculty of Rehabilitation, Kansai Medical UniversityFaculty of Rehabilitation, Kansai Medical UniversityAbstract Background Although many studies have explored the correlation between quality of life and survival, none have reported this relationship for specific cancers assessed at distinct time points. This meta-analysis aimed to investigate the impact of pretreatment Global Quality of Life (QOL) and functioning QOL, including physical, social, role, emotional, and cognitive QOLs, on mortality risk in patients with lung cancer. Methods A literature search was conducted across the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and PubMed databases for articles published between their inception and December 2022. Subsequently, 11 studies were selected based on predefined eligibility criteria to investigate the relationship between pretreatment QOLs and mortality risk in patients with lung cancer. Results Pretreatment global, physical, social, role, and emotional QOLs were significantly associated with mortality risk as follows: Global QOL (hazard ratio [HR] = 1.08 95% confidence interval [CI] = 1.03–1.13); Physical QOL (HR = 1.04 95% CI = 1.02–1.05); Social QOL (HR = 1.02 95% CI = 1.01–1.03; Role QOL (HR = 1.01 95% CI = 1.01–1.02); Emotional QOL (HR = 1.01 95% CI = 1.00–1.03). Conclusions These findings underscore the importance of early QOL assessment after diagnosis as well as early provision of physical, social, and psychological support accommodating each patient’s demands. Trial registration The International Prospective Register of Systematic Reviews registration number CRD42023398206, Registered on February 20, 2023.https://doi.org/10.1186/s12885-024-12267-wQuality of lifeLung cancerMortality riskSystematic reviewMeta-analysis |
| spellingShingle | Taro Okayama Katsuyoshi Suzuki Shinichiro Morishita Junichiro Inoue Takashi Tanaka Jiro Nakano Takuya Fukushima Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis BMC Cancer Quality of life Lung cancer Mortality risk Systematic review Meta-analysis |
| title | Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis |
| title_full | Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis |
| title_fullStr | Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis |
| title_short | Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis |
| title_sort | pretreatment quality of life and survival in patients with lung cancer a systematic review and meta analysis |
| topic | Quality of life Lung cancer Mortality risk Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12885-024-12267-w |
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