High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit
Considering that malnutrition (undernutrition) is common in stroke patients and may negatively impact body function, the aim of this study was to determine the relationship between nutritional risk and functional status in stroke patients at admission to a rehabilitation unit. Nutritional risk was a...
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/19/4144 |
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| author | Olivia Di Vincenzo Ermenegilda Pagano Mariarosaria Cervone Raffaele Natale Annadora Morena Alessandra Esposito Fabrizio Pasanisi Luca Scalfi |
| author_facet | Olivia Di Vincenzo Ermenegilda Pagano Mariarosaria Cervone Raffaele Natale Annadora Morena Alessandra Esposito Fabrizio Pasanisi Luca Scalfi |
| author_sort | Olivia Di Vincenzo |
| collection | DOAJ |
| description | Considering that malnutrition (undernutrition) is common in stroke patients and may negatively impact body function, the aim of this study was to determine the relationship between nutritional risk and functional status in stroke patients at admission to a rehabilitation unit. Nutritional risk was assessed using the Geriatric Nutritional Risk Index (GNRI), the Prognostic Nutritional Index (PNI) and the Controlling Nutritional Status (CONUT) score. Functional status was assessed using the Barthel Index, the modified Rankin Scale, the Trunk Control Test and the Sitting Balance Scale, and cognitive function was assessed using the Short Portable Mental Status Questionnaire. C-reactive protein, fibrinogen and D-dimer were also evaluated as established prognostic biomarkers. Stroke patients (n = 245; age 69.7 ± 12.8 years; 47%, women; 82% ischemic stroke) at admission to a rehabilitation unit were included in this study. A high prevalence of nutritional risk was detected with each tool and was found to be greater using the GNRI and in patients aged ≥75 years. Multiple logistic regression analysis showed that age and dysphagia were independent predictors of high nutritional risk. High risk groups performed worse on all functional tests compared to the low-risk groups (<i>p</i> < 0.05). Nutritional risk with each tool was associated with functional and cognitive statuses (with the highest correlation being with the Trunk Control Test). Significant associations were also found with C-reactive protein, fibrinogen and D-dimer. In conclusion, a high nutritional risk, as evaluated with the GNRI, the PNI and the CONUT score, was detected in stroke patients at admission to a rehabilitation unit. High nutritional risk was associated with functional status and with predictors of clinical outcomes (and specifically in older patients). |
| first_indexed | 2024-03-10T21:38:54Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T21:38:54Z |
| publishDate | 2023-09-01 |
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| series | Nutrients |
| spelling | doaj.art-9c5a08ab8c3c469ab533f3db5384326a2023-11-19T14:50:48ZengMDPI AGNutrients2072-66432023-09-011519414410.3390/nu15194144High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation UnitOlivia Di Vincenzo0Ermenegilda Pagano1Mariarosaria Cervone2Raffaele Natale3Annadora Morena4Alessandra Esposito5Fabrizio Pasanisi6Luca Scalfi7Department of Public Health, School of Medicine, Federico II University, via Sergio Pansini 5, 80131 Naples, ItalyCasa di Cura Santa Maria del Pozzo Hospital, via Pomigliano 40, Somma Vesuviana, 80049 Naples, ItalyCasa di Cura Santa Maria del Pozzo Hospital, via Pomigliano 40, Somma Vesuviana, 80049 Naples, ItalyDepartment of Clinical Medicine and Surgery, School of Medicine, Federico II University, via Sergio Pansini 5, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, School of Medicine, Federico II University, via Sergio Pansini 5, 80131 Naples, ItalyCasa di Cura Santa Maria del Pozzo Hospital, via Pomigliano 40, Somma Vesuviana, 80049 Naples, ItalyDepartment of Clinical Medicine and Surgery, School of Medicine, Federico II University, via Sergio Pansini 5, 80131 Naples, ItalyDepartment of Public Health, School of Medicine, Federico II University, via Sergio Pansini 5, 80131 Naples, ItalyConsidering that malnutrition (undernutrition) is common in stroke patients and may negatively impact body function, the aim of this study was to determine the relationship between nutritional risk and functional status in stroke patients at admission to a rehabilitation unit. Nutritional risk was assessed using the Geriatric Nutritional Risk Index (GNRI), the Prognostic Nutritional Index (PNI) and the Controlling Nutritional Status (CONUT) score. Functional status was assessed using the Barthel Index, the modified Rankin Scale, the Trunk Control Test and the Sitting Balance Scale, and cognitive function was assessed using the Short Portable Mental Status Questionnaire. C-reactive protein, fibrinogen and D-dimer were also evaluated as established prognostic biomarkers. Stroke patients (n = 245; age 69.7 ± 12.8 years; 47%, women; 82% ischemic stroke) at admission to a rehabilitation unit were included in this study. A high prevalence of nutritional risk was detected with each tool and was found to be greater using the GNRI and in patients aged ≥75 years. Multiple logistic regression analysis showed that age and dysphagia were independent predictors of high nutritional risk. High risk groups performed worse on all functional tests compared to the low-risk groups (<i>p</i> < 0.05). Nutritional risk with each tool was associated with functional and cognitive statuses (with the highest correlation being with the Trunk Control Test). Significant associations were also found with C-reactive protein, fibrinogen and D-dimer. In conclusion, a high nutritional risk, as evaluated with the GNRI, the PNI and the CONUT score, was detected in stroke patients at admission to a rehabilitation unit. High nutritional risk was associated with functional status and with predictors of clinical outcomes (and specifically in older patients).https://www.mdpi.com/2072-6643/15/19/4144malnutritionGNRIPNICONUTinflammationolder patients |
| spellingShingle | Olivia Di Vincenzo Ermenegilda Pagano Mariarosaria Cervone Raffaele Natale Annadora Morena Alessandra Esposito Fabrizio Pasanisi Luca Scalfi High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit Nutrients malnutrition GNRI PNI CONUT inflammation older patients |
| title | High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit |
| title_full | High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit |
| title_fullStr | High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit |
| title_full_unstemmed | High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit |
| title_short | High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit |
| title_sort | high nutritional risk is associated with poor functional status and prognostic biomarkers in stroke patients at admission to a rehabilitation unit |
| topic | malnutrition GNRI PNI CONUT inflammation older patients |
| url | https://www.mdpi.com/2072-6643/15/19/4144 |
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