Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children
Background Malaria is still an important cause of mortality and morbidity in children and adults in tropical countries. Multidrug resistance againts chloroquine and sulphadox- ine-pyrimethamine had brought to an introduction of artemisinin-based combination. Objective To assess the alternative treat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2008-08-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/575 |
| _version_ | 1811330787481485312 |
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| author | Jose Meky Mandei Novie Homenta Rampengan Suryadi Nicolaas Napoleon Tatura Ari Lukas Runtunuwu Tony Homenta Rampengan |
| author_facet | Jose Meky Mandei Novie Homenta Rampengan Suryadi Nicolaas Napoleon Tatura Ari Lukas Runtunuwu Tony Homenta Rampengan |
| author_sort | Jose Meky Mandei |
| collection | DOAJ |
| description | Background Malaria is still an important cause of mortality
and morbidity in children and adults in tropical countries.
Multidrug resistance againts chloroquine and sulphadox-
ine-pyrimethamine had brought to an introduction of
artemisinin-based combination.
Objective To assess the alternative treatment of uncompli-
cated falciparum malaria in children using artesunate and
sulphadoxine-pyrimethamine combination comparing to
artesunate and amodiaquine combination.
Methods This is a single-blind randomized trial. Sixty-
seven children aged six months to 13 years, were recruited.
Thirty-three children were treated with artesunate 4 mg/
kgbw/day for three days with an additional sulphadoxine-
pyrimethamine (pyrimethamine 1-1.5 mg/kgbw) single
dose on the first day, while 34 children were treated with
artesunate and amodiaquine base 10 mg/kgbw/day for the
first two days, then 5 mg/kgbw/day on the third day. Body
temperature and parasite count were recorded everyday
for at least seven days. The outcomes were fever clearance
time, parasite clearance time, cure rate and side effects. Sta-
tistical analysis was performed using the student t-test.
Results The statistical analysis showed that there were
no difference between these two groups either in fever
clearance time (P>0.05), or in parasite clearance time
(P>0.05). The cure rate was 100% in both groups. Vomit-
ing was found in one patient treated with artesunate and
amodiaquine combination.
Conclusion The combination of artesunate and sulpha-
doxine-pyrimethamine and combination of artesunate
and amodiaquine were found to be equally effective in the
treatment of uncomplicated falciparum malaria in children |
| first_indexed | 2024-04-13T16:08:12Z |
| format | Article |
| id | doaj.art-9c5c01f8413640c1a9ec1166ba529ad3 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-04-13T16:08:12Z |
| publishDate | 2008-08-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-9c5c01f8413640c1a9ec1166ba529ad32022-12-22T02:40:20ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2008-08-01484240510.14238/pi48.4.2008.240-5456Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in childrenJose Meky MandeiNovie Homenta RampenganSuryadi NicolaasNapoleon TaturaAri Lukas RuntunuwuTony Homenta RampenganBackground Malaria is still an important cause of mortality and morbidity in children and adults in tropical countries. Multidrug resistance againts chloroquine and sulphadox- ine-pyrimethamine had brought to an introduction of artemisinin-based combination. Objective To assess the alternative treatment of uncompli- cated falciparum malaria in children using artesunate and sulphadoxine-pyrimethamine combination comparing to artesunate and amodiaquine combination. Methods This is a single-blind randomized trial. Sixty- seven children aged six months to 13 years, were recruited. Thirty-three children were treated with artesunate 4 mg/ kgbw/day for three days with an additional sulphadoxine- pyrimethamine (pyrimethamine 1-1.5 mg/kgbw) single dose on the first day, while 34 children were treated with artesunate and amodiaquine base 10 mg/kgbw/day for the first two days, then 5 mg/kgbw/day on the third day. Body temperature and parasite count were recorded everyday for at least seven days. The outcomes were fever clearance time, parasite clearance time, cure rate and side effects. Sta- tistical analysis was performed using the student t-test. Results The statistical analysis showed that there were no difference between these two groups either in fever clearance time (P>0.05), or in parasite clearance time (P>0.05). The cure rate was 100% in both groups. Vomit- ing was found in one patient treated with artesunate and amodiaquine combination. Conclusion The combination of artesunate and sulpha- doxine-pyrimethamine and combination of artesunate and amodiaquine were found to be equally effective in the treatment of uncomplicated falciparum malaria in childrenhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/575uncomplicated falciparum malariaartesunatesulphadoxine-pyrimethamineamodiaquine |
| spellingShingle | Jose Meky Mandei Novie Homenta Rampengan Suryadi Nicolaas Napoleon Tatura Ari Lukas Runtunuwu Tony Homenta Rampengan Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children Paediatrica Indonesiana uncomplicated falciparum malaria artesunate sulphadoxine-pyrimethamine amodiaquine |
| title | Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| title_full | Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| title_fullStr | Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| title_full_unstemmed | Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| title_short | Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| title_sort | comparative efficacy of artesunate and sulphadoxine pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children |
| topic | uncomplicated falciparum malaria artesunate sulphadoxine-pyrimethamine amodiaquine |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/575 |
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