Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease
The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antib...
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MDPI AG
2020-03-01
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/691 |
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| author | Alma D. Del Angel-Pablo Ivette Buendía-Roldán Mayra Mejía Gloria Pérez-Rubio Karol J. Nava-Quiroz Jorge Rojas-Serrano Ramcés Falfán-Valencia |
| author_facet | Alma D. Del Angel-Pablo Ivette Buendía-Roldán Mayra Mejía Gloria Pérez-Rubio Karol J. Nava-Quiroz Jorge Rojas-Serrano Ramcés Falfán-Valencia |
| author_sort | Alma D. Del Angel-Pablo |
| collection | DOAJ |
| description | The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI/mL) was higher in the RA group in comparison to RA-ILD (<i>p</i> < 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, <i>p</i> = 0.02, r<sup>2</sup> = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD. |
| first_indexed | 2024-03-12T08:29:58Z |
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| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:29:58Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj.art-9c5d8058782d4a85b6b858bbc56233dc2023-09-02T17:50:10ZengMDPI AGCells2073-44092020-03-019369110.3390/cells9030691cells9030691Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung DiseaseAlma D. Del Angel-Pablo0Ivette Buendía-Roldán1Mayra Mejía2Gloria Pérez-Rubio3Karol J. Nava-Quiroz4Jorge Rojas-Serrano5Ramcés Falfán-Valencia6HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 Mexico City, MexicoTranslational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, MexicoInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 Mexico City, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 Mexico City, MexicoInterstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 Mexico City, MexicoThe pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI/mL) was higher in the RA group in comparison to RA-ILD (<i>p</i> < 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, <i>p</i> = 0.02, r<sup>2</sup> = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD.https://www.mdpi.com/2073-4409/9/3/691anti-hla antibodiespanel-reactive antibodiesc-reactive proteinrheumatoid arthritisinterstitial lung diseaseanti-ccp+pra |
| spellingShingle | Alma D. Del Angel-Pablo Ivette Buendía-Roldán Mayra Mejía Gloria Pérez-Rubio Karol J. Nava-Quiroz Jorge Rojas-Serrano Ramcés Falfán-Valencia Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease Cells anti-hla antibodies panel-reactive antibodies c-reactive protein rheumatoid arthritis interstitial lung disease anti-ccp+ pra |
| title | Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease |
| title_full | Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease |
| title_fullStr | Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease |
| title_full_unstemmed | Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease |
| title_short | Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease |
| title_sort | anti hla class ii antibodies correlate with c reactive protein levels in patients with rheumatoid arthritis associated with interstitial lung disease |
| topic | anti-hla antibodies panel-reactive antibodies c-reactive protein rheumatoid arthritis interstitial lung disease anti-ccp+ pra |
| url | https://www.mdpi.com/2073-4409/9/3/691 |
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