Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor
PurposeVitamin D prevents hypocalcaemia, osteoporosis, and infections, among other problems, and is involved in the prevention and treatment of cardiovascular and neurological diseases. Recently, vitamin D was shown to improve cognitive dysfunction caused by Alzheimer's disease and vascular dem...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.893309/full |
| _version_ | 1817987295950667776 |
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| author | Jialei Zhang Jialei Zhang Xiaoling Zhang Yongyan Yang Jun Zhao Yonghao Yu |
| author_facet | Jialei Zhang Jialei Zhang Xiaoling Zhang Yongyan Yang Jun Zhao Yonghao Yu |
| author_sort | Jialei Zhang |
| collection | DOAJ |
| description | PurposeVitamin D prevents hypocalcaemia, osteoporosis, and infections, among other problems, and is involved in the prevention and treatment of cardiovascular and neurological diseases. Recently, vitamin D was shown to improve cognitive dysfunction caused by Alzheimer's disease and vascular dementia. This study aims to explore the correlation between preoperative serum vitamin D and postoperative cognitive disorder (POCD) occurrence in elderly patients with gastrointestinal tumors to guide perioperative medication use and promote early patient recovery.MethodsThis study recruited 238 elderly patients (65 ≤ age ≤ 85) who underwent gastrointestinal tumor surgery; 117 cases were enrolled, and 55 controls of the same age and education level as the cases were included. Blood samples were taken preoperatively and at 7, 15, 30, and 90 days postoperatively, and plasma vitamin D (25OH-D3) and glutathione (GSH) was measured. Different from the previous diagnosis of POCD was obtained by telephone interview through Cognitive Status Modified Telephone Interview (TICS-m), mainly for memory impairment, a series of neuropsychological tests was used to evaluate cognitive function, Picture Recollect Test, Stroop Color-word Test, and Digit Symbol Substitution Test were used to comprehensively evaluate the three domains of cognitive function of patients, namely memory, attention and information processing ability. All neuropsychiatric assessments were performed at the bedside and completed face-to-face by the assessment staff and the patient.ResultsA total of 65.8% (77/117) of elderly patients undergoing gastrointestinal tumor surgery had preoperative vitamin D deficiency (serum 25OH-D concentration < 12 ng/ml), of whom 46.7% (36/77, 7 days after surgery), 31.2% (24/77, 15 days after surgery), 15.6% (12/77, 30 days after surgery), and 9% (7/77, 90 days after surgery) of patients developed POCD; 7.5% (3/40) of patients without vitamin D deficiency developed PNDs, which was detected only on the 7th day after surgery.ConclusionsVitamin D deficiency can increase neurocognitive disorder risk in elderly patients during the perioperative period, possibly because low vitamin D levels cannot effectively inhibit the postoperative oxidative stress increase.Trial RegistrationThis experiment was approved and registered by the China Clinical Trial Registration Center, registration number ChiCTR2100046900 (30/05/2021). |
| first_indexed | 2024-04-14T00:20:17Z |
| format | Article |
| id | doaj.art-9c5d917f8da14607a82c89a4b790321f |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-14T00:20:17Z |
| publishDate | 2022-04-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-9c5d917f8da14607a82c89a4b790321f2022-12-22T02:22:59ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.893309893309Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal TumorJialei Zhang0Jialei Zhang1Xiaoling Zhang2Yongyan Yang3Jun Zhao4Yonghao Yu5Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Anesthesiology, Changzhi People's Hospital Affiliated to Shanxi Medical University, Changzhi, ChinaDepartment of Oncology, Changzhi People's Hospital Affiliated to Shanxi Medical University, Changzhi, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Oncology, Changzhi People's Hospital Affiliated to Shanxi Medical University, Changzhi, ChinaDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, ChinaPurposeVitamin D prevents hypocalcaemia, osteoporosis, and infections, among other problems, and is involved in the prevention and treatment of cardiovascular and neurological diseases. Recently, vitamin D was shown to improve cognitive dysfunction caused by Alzheimer's disease and vascular dementia. This study aims to explore the correlation between preoperative serum vitamin D and postoperative cognitive disorder (POCD) occurrence in elderly patients with gastrointestinal tumors to guide perioperative medication use and promote early patient recovery.MethodsThis study recruited 238 elderly patients (65 ≤ age ≤ 85) who underwent gastrointestinal tumor surgery; 117 cases were enrolled, and 55 controls of the same age and education level as the cases were included. Blood samples were taken preoperatively and at 7, 15, 30, and 90 days postoperatively, and plasma vitamin D (25OH-D3) and glutathione (GSH) was measured. Different from the previous diagnosis of POCD was obtained by telephone interview through Cognitive Status Modified Telephone Interview (TICS-m), mainly for memory impairment, a series of neuropsychological tests was used to evaluate cognitive function, Picture Recollect Test, Stroop Color-word Test, and Digit Symbol Substitution Test were used to comprehensively evaluate the three domains of cognitive function of patients, namely memory, attention and information processing ability. All neuropsychiatric assessments were performed at the bedside and completed face-to-face by the assessment staff and the patient.ResultsA total of 65.8% (77/117) of elderly patients undergoing gastrointestinal tumor surgery had preoperative vitamin D deficiency (serum 25OH-D concentration < 12 ng/ml), of whom 46.7% (36/77, 7 days after surgery), 31.2% (24/77, 15 days after surgery), 15.6% (12/77, 30 days after surgery), and 9% (7/77, 90 days after surgery) of patients developed POCD; 7.5% (3/40) of patients without vitamin D deficiency developed PNDs, which was detected only on the 7th day after surgery.ConclusionsVitamin D deficiency can increase neurocognitive disorder risk in elderly patients during the perioperative period, possibly because low vitamin D levels cannot effectively inhibit the postoperative oxidative stress increase.Trial RegistrationThis experiment was approved and registered by the China Clinical Trial Registration Center, registration number ChiCTR2100046900 (30/05/2021).https://www.frontiersin.org/articles/10.3389/fpsyt.2022.893309/fullelderly populationperioperativevitamin DGSHPOCD |
| spellingShingle | Jialei Zhang Jialei Zhang Xiaoling Zhang Yongyan Yang Jun Zhao Yonghao Yu Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor Frontiers in Psychiatry elderly population perioperative vitamin D GSH POCD |
| title | Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor |
| title_full | Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor |
| title_fullStr | Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor |
| title_full_unstemmed | Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor |
| title_short | Correlation Analysis of Serum Vitamin D Levels and Postoperative Cognitive Disorder in Elderly Patients With Gastrointestinal Tumor |
| title_sort | correlation analysis of serum vitamin d levels and postoperative cognitive disorder in elderly patients with gastrointestinal tumor |
| topic | elderly population perioperative vitamin D GSH POCD |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.893309/full |
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