Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients
Background. Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices. Methods...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2022/1459410 |
| _version_ | 1827008269975027712 |
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| author | Hiva Danesh Nasrin Ziamajidi Seyed Alireza Mesbah-Namin Nahid Nafisi Roghayeh Abbasalipourkabir |
| author_facet | Hiva Danesh Nasrin Ziamajidi Seyed Alireza Mesbah-Namin Nahid Nafisi Roghayeh Abbasalipourkabir |
| author_sort | Hiva Danesh |
| collection | DOAJ |
| description | Background. Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices. Methods. This case-control study included 43 women with breast cancer and 37 age-matched healthy controls. Oxidative stress and its correlation with hematological profiles over seven months were evaluated. Finally, the data were compared between the two groups using the t-test and Pearson’s test, and the results were analyzed using the SPSS 24 software. Results. The results revealed that patients with breast cancer had significantly increased hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels compared with healthy subjects (p<0.05). In addition, oxidative stress parameters, such as superoxide dismutase (SOD), catalase (CAT), total oxidant status (TOS), and total antioxidant capacity (TAC), were significantly elevated. Glutathione peroxidase (GPX) and malondialdehyde (MDA) were significantly lower in patients with breast cancer than in the control group (p<0.05). Statistical significance in hematological indices showed a positive or negative correlation with oxidative stress parameters. Conclusion. Women with breast cancer showed a deranged complete blood count (CBC) pattern compared to healthy individuals. |
| first_indexed | 2024-04-11T09:35:56Z |
| format | Article |
| id | doaj.art-9c60b1a7d23649528ca31154b29948ca |
| institution | Directory Open Access Journal |
| issn | 2090-3189 |
| language | English |
| last_indexed | 2025-02-18T12:31:26Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj.art-9c60b1a7d23649528ca31154b29948ca2024-11-02T04:15:41ZengHindawi LimitedInternational Journal of Breast Cancer2090-31892022-01-01202210.1155/2022/1459410Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer PatientsHiva Danesh0Nasrin Ziamajidi1Seyed Alireza Mesbah-Namin2Nahid Nafisi3Roghayeh Abbasalipourkabir4Department of Clinical BiochemistryDepartment of Clinical BiochemistryDepartment of Clinical BiochemistryDepartment of General SurgeryDepartment of Clinical BiochemistryBackground. Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices. Methods. This case-control study included 43 women with breast cancer and 37 age-matched healthy controls. Oxidative stress and its correlation with hematological profiles over seven months were evaluated. Finally, the data were compared between the two groups using the t-test and Pearson’s test, and the results were analyzed using the SPSS 24 software. Results. The results revealed that patients with breast cancer had significantly increased hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels compared with healthy subjects (p<0.05). In addition, oxidative stress parameters, such as superoxide dismutase (SOD), catalase (CAT), total oxidant status (TOS), and total antioxidant capacity (TAC), were significantly elevated. Glutathione peroxidase (GPX) and malondialdehyde (MDA) were significantly lower in patients with breast cancer than in the control group (p<0.05). Statistical significance in hematological indices showed a positive or negative correlation with oxidative stress parameters. Conclusion. Women with breast cancer showed a deranged complete blood count (CBC) pattern compared to healthy individuals.http://dx.doi.org/10.1155/2022/1459410 |
| spellingShingle | Hiva Danesh Nasrin Ziamajidi Seyed Alireza Mesbah-Namin Nahid Nafisi Roghayeh Abbasalipourkabir Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients International Journal of Breast Cancer |
| title | Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients |
| title_full | Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients |
| title_fullStr | Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients |
| title_full_unstemmed | Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients |
| title_short | Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients |
| title_sort | association between oxidative stress parameters and hematological indices in breast cancer patients |
| url | http://dx.doi.org/10.1155/2022/1459410 |
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