Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends
Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient’s quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP’s) which have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8480 |
| _version_ | 1797548279712448512 |
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| author | Benjamin Scaria Siddhartha Sood Christopher Raad Jana Khanafer Rahul Jayachandiran Alaina Pupulin Sahibjot Grewal Michael Okoko Mansi Arora Lauren Miles Siyaram Pandey |
| author_facet | Benjamin Scaria Siddhartha Sood Christopher Raad Jana Khanafer Rahul Jayachandiran Alaina Pupulin Sahibjot Grewal Michael Okoko Mansi Arora Lauren Miles Siyaram Pandey |
| author_sort | Benjamin Scaria |
| collection | DOAJ |
| description | Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient’s quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP’s) which have demonstrated the ability to selectively target cancer cells in cellular and animal models. However, the major hurdle of clinical validation remains. NHP’s warrant further clinical investigation as a therapeutic option since they exhibit low toxicity, while retaining a selective effect. Additionally, they can sensitize cancerous cells to chemotherapy, which enhances the efficacy of chemotherapeutic drugs, indicating that they can be utilized as supplemental therapy. An additional area for further research is the investigation of drug–drug interactions between NHP’s and chemotherapeutics. The objectives of this review are to report the most recent results from the field of anticancer NHP research, and to highlight the most recent advancements in possible supplemental therapeutic options. |
| first_indexed | 2024-03-10T14:56:02Z |
| format | Article |
| id | doaj.art-9c61749222af4f72ba55547a84e89f46 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:56:02Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9c61749222af4f72ba55547a84e89f462023-11-20T20:33:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122848010.3390/ijms21228480Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall TrendsBenjamin Scaria0Siddhartha Sood1Christopher Raad2Jana Khanafer3Rahul Jayachandiran4Alaina Pupulin5Sahibjot Grewal6Michael Okoko7Mansi Arora8Lauren Miles9Siyaram Pandey10Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaMost cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient’s quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP’s) which have demonstrated the ability to selectively target cancer cells in cellular and animal models. However, the major hurdle of clinical validation remains. NHP’s warrant further clinical investigation as a therapeutic option since they exhibit low toxicity, while retaining a selective effect. Additionally, they can sensitize cancerous cells to chemotherapy, which enhances the efficacy of chemotherapeutic drugs, indicating that they can be utilized as supplemental therapy. An additional area for further research is the investigation of drug–drug interactions between NHP’s and chemotherapeutics. The objectives of this review are to report the most recent results from the field of anticancer NHP research, and to highlight the most recent advancements in possible supplemental therapeutic options.https://www.mdpi.com/1422-0067/21/22/8480complementary and alternative medicine (CAM)cancernatural compoundintegrative oncologynatural health product (NHP)apoptosis |
| spellingShingle | Benjamin Scaria Siddhartha Sood Christopher Raad Jana Khanafer Rahul Jayachandiran Alaina Pupulin Sahibjot Grewal Michael Okoko Mansi Arora Lauren Miles Siyaram Pandey Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends International Journal of Molecular Sciences complementary and alternative medicine (CAM) cancer natural compound integrative oncology natural health product (NHP) apoptosis |
| title | Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends |
| title_full | Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends |
| title_fullStr | Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends |
| title_full_unstemmed | Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends |
| title_short | Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends |
| title_sort | natural health products nhp s and natural compounds as therapeutic agents for the treatment of cancer mechanisms of anti cancer activity of natural compounds and overall trends |
| topic | complementary and alternative medicine (CAM) cancer natural compound integrative oncology natural health product (NHP) apoptosis |
| url | https://www.mdpi.com/1422-0067/21/22/8480 |
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