Two-Component Response Regulator OmpR Regulates Mucoviscosity through Energy Metabolism in Klebsiella pneumoniae

Two-Component Response Regulator OmpR Regulates Mucoviscosity through Energy Metabolism in Klebsiella pneumoniae

ABSTRACT Hypermucoviscosity is a hallmark of hypervirulent Klebsiella pneumoniae (hvKP). However, the molecular basis of its regulation is largely unknown. We hypothesize that hypermucoviscosity is modulated via two-component signal transduction systems (TCSs). In-frame deletion mutants of all 33 re...

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Bibliographic Details
Main Authors: Lijun Wang, Xueting Huang, Qian Jin, Jie Tang, Hua Zhang, Jing-Ren Zhang, Hui Wu
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Klebsiella pneumoniae
hypermucoviscosity
OmpR
F-type ATP synthase
glycine cleavage system
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00544-23

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