Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study
Parkinson’s disease (PD) is a chronic neurodegenerative disorder that results in important functional symptoms, altered mood, and deterioration in quality of life (QoL). This study aimed to determine the evolution of the QoL in persons with PD in the Albacete health district over a two-year period a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/9/1824 |
| _version_ | 1797536728330797056 |
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| author | Eduardo Candel-Parra María Pilar Córcoles-Jiménez Victoria Delicado-Useros Antonio Hernández-Martínez Milagros Molina-Alarcón |
| author_facet | Eduardo Candel-Parra María Pilar Córcoles-Jiménez Victoria Delicado-Useros Antonio Hernández-Martínez Milagros Molina-Alarcón |
| author_sort | Eduardo Candel-Parra |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a chronic neurodegenerative disorder that results in important functional symptoms, altered mood, and deterioration in quality of life (QoL). This study aimed to determine the evolution of the QoL in persons with PD in the Albacete health district over a two-year period and identify associated sociodemographic, clinical, and socio-health characteristics. A cohort study was conducted of patients at different stages of PD in the Albacete health district. Calculated sample size: 155 patients. Instruments: A purpose-designed questionnaire for data collection and the “Parkinson Disease Questionnaire” (PDQ-39), which measures 8 dimensions and a global index where a higher score indicates worse quality of life. Three measurements were made: baseline, one year, two years. A descriptive and bivariate analysis was conducted. Ethical aspects: informed consent, anonymized data. Results: Mean age 69.51 (standard deviation, SD 8.73) years, 60% male, 75.5% married, and 85.5% lived with family. The most frequent motor symptoms were slow movement (86.23%), postural instability (55.5%), tremor (45.5%), and dyskinesia (24.6%). Among the non-motor symptoms were fatigue (66.2%), pain, daytime somnolence, constipation, and apathy, with approximately 50% each. The mean QoL score at baseline was 27.47 (SD 16.14); 95% CI (confidence interval) 24.91–30.03. At two years, global QoL had slightly worsened (28.3; SD 17.26; 95% CI 25.41–31.18), with a statistically significant worsening in mobility, activities of daily living, and communication, whereas social support improved. |
| first_indexed | 2024-03-10T12:04:55Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:04:55Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9c64bf47c62742be8077a678e5225b2f2023-11-21T16:40:17ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01109182410.3390/jcm10091824Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort StudyEduardo Candel-Parra0María Pilar Córcoles-Jiménez1Victoria Delicado-Useros2Antonio Hernández-Martínez3Milagros Molina-Alarcón4Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, Av. de España, 02001 Albacete, SpainDepartment of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, Av. de España, 02001 Albacete, SpainDepartment of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, Av. de España, 02001 Albacete, SpainDepartment of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, SpainDepartment of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, Av. de España, 02001 Albacete, SpainParkinson’s disease (PD) is a chronic neurodegenerative disorder that results in important functional symptoms, altered mood, and deterioration in quality of life (QoL). This study aimed to determine the evolution of the QoL in persons with PD in the Albacete health district over a two-year period and identify associated sociodemographic, clinical, and socio-health characteristics. A cohort study was conducted of patients at different stages of PD in the Albacete health district. Calculated sample size: 155 patients. Instruments: A purpose-designed questionnaire for data collection and the “Parkinson Disease Questionnaire” (PDQ-39), which measures 8 dimensions and a global index where a higher score indicates worse quality of life. Three measurements were made: baseline, one year, two years. A descriptive and bivariate analysis was conducted. Ethical aspects: informed consent, anonymized data. Results: Mean age 69.51 (standard deviation, SD 8.73) years, 60% male, 75.5% married, and 85.5% lived with family. The most frequent motor symptoms were slow movement (86.23%), postural instability (55.5%), tremor (45.5%), and dyskinesia (24.6%). Among the non-motor symptoms were fatigue (66.2%), pain, daytime somnolence, constipation, and apathy, with approximately 50% each. The mean QoL score at baseline was 27.47 (SD 16.14); 95% CI (confidence interval) 24.91–30.03. At two years, global QoL had slightly worsened (28.3; SD 17.26; 95% CI 25.41–31.18), with a statistically significant worsening in mobility, activities of daily living, and communication, whereas social support improved.https://www.mdpi.com/2077-0383/10/9/1824Parkinson’s diseasequality of lifePDQ 39motor symptomsno-motor symptoms |
| spellingShingle | Eduardo Candel-Parra María Pilar Córcoles-Jiménez Victoria Delicado-Useros Antonio Hernández-Martínez Milagros Molina-Alarcón Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study Journal of Clinical Medicine Parkinson’s disease quality of life PDQ 39 motor symptoms no-motor symptoms |
| title | Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study |
| title_full | Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study |
| title_fullStr | Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study |
| title_full_unstemmed | Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study |
| title_short | Evolution of Quality of Life in Persons with Parkinson’s Disease: A Prospective Cohort Study |
| title_sort | evolution of quality of life in persons with parkinson s disease a prospective cohort study |
| topic | Parkinson’s disease quality of life PDQ 39 motor symptoms no-motor symptoms |
| url | https://www.mdpi.com/2077-0383/10/9/1824 |
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