The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties
Background and purpose: Minoxidil is one of the agents that can treat hair growth disorders, including alopecia, by increasing the anagen period. Due to the nature of minoxidil, the permeability of the drug to the skin surface is negligible. Therefore, the purpose of this study was to design and eva...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-11-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-19328-en.pdf |
| _version_ | 1797561661103538176 |
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| author | Anayatollah Salimi Eskandar Moghimipour Ali Talebpour Jahromi Saeed Mohammad Soleymani |
| author_facet | Anayatollah Salimi Eskandar Moghimipour Ali Talebpour Jahromi Saeed Mohammad Soleymani |
| author_sort | Anayatollah Salimi |
| collection | DOAJ |
| description | Background and purpose: Minoxidil is one of the agents that can treat hair growth disorders, including alopecia, by increasing the anagen period. Due to the nature of minoxidil, the permeability of the drug to the skin surface is negligible. Therefore, the purpose of this study was to design and evaluate microemulsion formulations in order to increase skin permeability of minoxidil.
Materials and methods: Microemulsions containing 2% minoxidil were prepared with an appropriate amount of oil phase, surfactant, and co-surfactant. The medicinal substance was dissolved in the oily phase. The physicochemical properties of the microemulsions, including particle size, viscosity, release, skin permeation through rat skin as well as the rate of drug permeation through rat skin, were evaluated using Franz cells.
Results: The particle size of microemulsions was in the range of 5.45-10.4 nm, viscosity was 113.2-199.2 centipoise. This study showed that the parameters of drug release percentage in the second hour, drug release percentage in the 24th hour, viscosity and Dapp were significantly related to independent variables(P<0.05). Increasing the percentage of water and the percentage of oil has increased the amount of drug release in 24 hours. Increasing the percentage of oil and decreasing the percentage of water can lead to an increase in viscosity, and increasing the percentage of water can increase the amount of Dapp in microemulsions.
Conclusion: The prepared formulations were able to significantly increase the skin permeability of minoxidil. |
| first_indexed | 2024-03-10T18:18:04Z |
| format | Article |
| id | doaj.art-9c64eba74ade4dbdb35cd3513ce01f44 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T18:18:04Z |
| publishDate | 2023-11-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-9c64eba74ade4dbdb35cd3513ce01f442023-11-20T07:33:34ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-11-01332265263The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical PropertiesAnayatollah Salimi0Eskandar Moghimipour1Ali Talebpour Jahromi2Saeed Mohammad Soleymani3 Associate Professor, Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ، Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ، Professor, Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Doctor of Pharmacy, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Resident in Clinical Pharmacy, School of PharmacyShahid Beheshti University of Medical Sciences, Tehran, Iran Background and purpose: Minoxidil is one of the agents that can treat hair growth disorders, including alopecia, by increasing the anagen period. Due to the nature of minoxidil, the permeability of the drug to the skin surface is negligible. Therefore, the purpose of this study was to design and evaluate microemulsion formulations in order to increase skin permeability of minoxidil. Materials and methods: Microemulsions containing 2% minoxidil were prepared with an appropriate amount of oil phase, surfactant, and co-surfactant. The medicinal substance was dissolved in the oily phase. The physicochemical properties of the microemulsions, including particle size, viscosity, release, skin permeation through rat skin as well as the rate of drug permeation through rat skin, were evaluated using Franz cells. Results: The particle size of microemulsions was in the range of 5.45-10.4 nm, viscosity was 113.2-199.2 centipoise. This study showed that the parameters of drug release percentage in the second hour, drug release percentage in the 24th hour, viscosity and Dapp were significantly related to independent variables(P<0.05). Increasing the percentage of water and the percentage of oil has increased the amount of drug release in 24 hours. Increasing the percentage of oil and decreasing the percentage of water can lead to an increase in viscosity, and increasing the percentage of water can increase the amount of Dapp in microemulsions. Conclusion: The prepared formulations were able to significantly increase the skin permeability of minoxidil.http://jmums.mazums.ac.ir/article-1-19328-en.pdfminoxidilmicroemulsiontransdermal drug deliverynano drug delivery system |
| spellingShingle | Anayatollah Salimi Eskandar Moghimipour Ali Talebpour Jahromi Saeed Mohammad Soleymani The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties Journal of Mazandaran University of Medical Sciences minoxidil microemulsion transdermal drug delivery nano drug delivery system |
| title | The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties |
| title_full | The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties |
| title_fullStr | The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties |
| title_full_unstemmed | The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties |
| title_short | The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties |
| title_sort | design of minoxidil microemulsion formulation and the effects of ingredients on the permeability of rat skin and its physicochemical properties |
| topic | minoxidil microemulsion transdermal drug delivery nano drug delivery system |
| url | http://jmums.mazums.ac.ir/article-1-19328-en.pdf |
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