MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors
Background: Salivary gland tumors bear uncanny characteristics of being different based on their morphological aspects rather than the presence of clear demarcation. This ambiguity in the spectrum from benign to malignant salivary gland neoplasms while categorizing the neoplasm is having inherent pi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=1;spage=22;epage=27;aulast=Raja |
| _version_ | 1818949552340729856 |
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| author | Ritika Raja Devi Charan Shetty Chandrakanta Saurabh Juneja Ankita Tandon Nikita Gulati |
| author_facet | Ritika Raja Devi Charan Shetty Chandrakanta Saurabh Juneja Ankita Tandon Nikita Gulati |
| author_sort | Ritika Raja |
| collection | DOAJ |
| description | Background: Salivary gland tumors bear uncanny characteristics of being different based on their morphological aspects rather than the presence of clear demarcation. This ambiguity in the spectrum from benign to malignant salivary gland neoplasms while categorizing the neoplasm is having inherent pitfalls. The present study was, therefore, designed to characterize benign and malignant salivary gland tumors based on their proliferative indices. Materials and Method: Study samples comprised of 97 cases of histopathologically confirmed benign and malignant salivary gland tumors. The cases were immunohistochemically assessed for MCM3 and Ki-67 expressions and the molecular characterization was performed based on the findings. Results: The majority of benign and malignant salivary gland tumors were from the parotid gland, (51.2%) and (42.4%), respectively. Overall mean labeling index of MCM3 was higher i.e., (5.60 ± 3.99) in comparison to Ki-67 i.e., (2.82 ± 3.14) with P = 0.05 using paired t-test. Besides, malignant salivary gland neoplasms represented a higher mean score of MCM3 and Ki-67 than benign neoplasms. Conclusion: The requirement of a novel marker has led to the use of MCM3 which has a characteristic role in the entire spectrum of the cell cycle. The present study highlighted the extrapolation of MCM3 over Ki-67 for diagnosis and for true characterization of biologic behavior of salivary gland pathologies which may, in turn, influence the treatment modality employed for such lesions. |
| first_indexed | 2024-12-20T09:04:30Z |
| format | Article |
| id | doaj.art-9c6585d9b27947f88b7496b1e147a979 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-20T09:04:30Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-9c6585d9b27947f88b7496b1e147a9792022-12-21T19:45:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292021-01-01641222710.4103/IJPM.IJPM_63_20MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumorsRitika RajaDevi Charan ShettyChandrakantaSaurabh JunejaAnkita TandonNikita GulatiBackground: Salivary gland tumors bear uncanny characteristics of being different based on their morphological aspects rather than the presence of clear demarcation. This ambiguity in the spectrum from benign to malignant salivary gland neoplasms while categorizing the neoplasm is having inherent pitfalls. The present study was, therefore, designed to characterize benign and malignant salivary gland tumors based on their proliferative indices. Materials and Method: Study samples comprised of 97 cases of histopathologically confirmed benign and malignant salivary gland tumors. The cases were immunohistochemically assessed for MCM3 and Ki-67 expressions and the molecular characterization was performed based on the findings. Results: The majority of benign and malignant salivary gland tumors were from the parotid gland, (51.2%) and (42.4%), respectively. Overall mean labeling index of MCM3 was higher i.e., (5.60 ± 3.99) in comparison to Ki-67 i.e., (2.82 ± 3.14) with P = 0.05 using paired t-test. Besides, malignant salivary gland neoplasms represented a higher mean score of MCM3 and Ki-67 than benign neoplasms. Conclusion: The requirement of a novel marker has led to the use of MCM3 which has a characteristic role in the entire spectrum of the cell cycle. The present study highlighted the extrapolation of MCM3 over Ki-67 for diagnosis and for true characterization of biologic behavior of salivary gland pathologies which may, in turn, influence the treatment modality employed for such lesions.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=1;spage=22;epage=27;aulast=Rajamcm3neoplasmski-67salivary gland |
| spellingShingle | Ritika Raja Devi Charan Shetty Chandrakanta Saurabh Juneja Ankita Tandon Nikita Gulati MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors Indian Journal of Pathology and Microbiology mcm3 neoplasms ki-67 salivary gland |
| title | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors |
| title_full | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors |
| title_fullStr | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors |
| title_full_unstemmed | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors |
| title_short | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors |
| title_sort | mcm3 proliferative index is worthier over ki 67 in the characterization of salivary gland tumors |
| topic | mcm3 neoplasms ki-67 salivary gland |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=1;spage=22;epage=27;aulast=Raja |
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