Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors
Aim. To present the results of the complex assessment of the associations between arterial wall structure and metabolic, infectious, and immune parameters in people free from cardiovascular risk factors (RFs). Material and methods. Among 400 examined healthy participants, aged 18-65 years, 25 did no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2155 |
| _version_ | 1797882824482619392 |
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| author | A. P. Shavrin B. V. Golovskoy Ya. B. Khovaeva |
| author_facet | A. P. Shavrin B. V. Golovskoy Ya. B. Khovaeva |
| author_sort | A. P. Shavrin |
| collection | DOAJ |
| description | Aim. To present the results of the complex assessment of the associations between arterial wall structure and metabolic, infectious, and immune parameters in people free from cardiovascular risk factors (RFs). Material and methods. Among 400 examined healthy participants, aged 18-65 years, 25 did not have any cardiovascular RFs. Vascular ultrasound, with intima-media thickness (IMT) measurement, was performed using ALOKA 5000 device. Laboratory parameters included lipid profile, glucose, plasma C-reactive protein (CRP), pro-inflammatory cytokines, and specific IgG antibodies to CMV, HCV-1, Cl. pneumoniae, H. рylori, and β-streptococcus. Immune status was assessed by innate and acquired immune parameters. Results. A strong association between IMT and viral infectious factors (CMV and HCV-1) was observed. The interaction between infectious factors and arterial wall also involves blood lipids (triglycerides, low- and highdensity lipoprotein cholesterol, total cholesterol) and innate and acquired immune factors. Immune factors regulate vascular wall hemostasis, possibly controlling viral replication and preventing vascular inflammation. This hypothesis is confirmed by low levels of CRP and pro-inflammatory cytokines, as well as by no association between arterial wall thickness and inflammation markers. Conclusion. In healthy subjects without RFs, vascular wall is interacting with viral infectious factors, innate and acquired immune parameters, blood lipids and glucose. All these interactions are balanced and, therefore, do not result in intravascular inflammation. |
| first_indexed | 2024-04-10T03:41:53Z |
| format | Article |
| id | doaj.art-9c65abc61eee423d8e3e5557ac0f05c0 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:53Z |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-9c65abc61eee423d8e3e5557ac0f05c02023-03-13T07:23:10Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-0197481864Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factorsA. P. Shavrin0B. V. Golovskoy1Ya. B. Khovaeva2Пермская государственная медицинская академия им. ак. Е.А.Вагнера Росздрава. ПермьПермская государственная медицинская академия им. ак. Е.А.Вагнера Росздрава. ПермьПермская государственная медицинская академия им. ак. Е.А.Вагнера Росздрава. ПермьAim. To present the results of the complex assessment of the associations between arterial wall structure and metabolic, infectious, and immune parameters in people free from cardiovascular risk factors (RFs). Material and methods. Among 400 examined healthy participants, aged 18-65 years, 25 did not have any cardiovascular RFs. Vascular ultrasound, with intima-media thickness (IMT) measurement, was performed using ALOKA 5000 device. Laboratory parameters included lipid profile, glucose, plasma C-reactive protein (CRP), pro-inflammatory cytokines, and specific IgG antibodies to CMV, HCV-1, Cl. pneumoniae, H. рylori, and β-streptococcus. Immune status was assessed by innate and acquired immune parameters. Results. A strong association between IMT and viral infectious factors (CMV and HCV-1) was observed. The interaction between infectious factors and arterial wall also involves blood lipids (triglycerides, low- and highdensity lipoprotein cholesterol, total cholesterol) and innate and acquired immune factors. Immune factors regulate vascular wall hemostasis, possibly controlling viral replication and preventing vascular inflammation. This hypothesis is confirmed by low levels of CRP and pro-inflammatory cytokines, as well as by no association between arterial wall thickness and inflammation markers. Conclusion. In healthy subjects without RFs, vascular wall is interacting with viral infectious factors, innate and acquired immune parameters, blood lipids and glucose. All these interactions are balanced and, therefore, do not result in intravascular inflammation.https://cardiovascular.elpub.ru/jour/article/view/2155сосудистая стенкапрактически здоровые лицалатентные вирусные инфекциииммунная системаатеросклероз |
| spellingShingle | A. P. Shavrin B. V. Golovskoy Ya. B. Khovaeva Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors Кардиоваскулярная терапия и профилактика сосудистая стенка практически здоровые лица латентные вирусные инфекции иммунная система атеросклероз |
| title | Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors |
| title_full | Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors |
| title_fullStr | Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors |
| title_full_unstemmed | Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors |
| title_short | Associations between intima-media thickness of carotid arteries, infectious, immune, and metabolic parameters in healthy people with no risk factors |
| title_sort | associations between intima media thickness of carotid arteries infectious immune and metabolic parameters in healthy people with no risk factors |
| topic | сосудистая стенка практически здоровые лица латентные вирусные инфекции иммунная система атеросклероз |
| url | https://cardiovascular.elpub.ru/jour/article/view/2155 |
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