Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block
<p><strong>Background and Objecive: </strong>Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a convenient, less invasive and better diagnostic tool. This study was carried out to determine the d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Discover STM Publishing Ltd
2021-03-01
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| Series: | BioMedica |
| Online Access: | https://biomedicapk.com/10.51441/BioMedica/5-166 |
| _version_ | 1827763513199689728 |
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| author | Saniyah Ali Nausheen Henna Uzma Aslam Tayabba Rashid Urfa Shafi Naveed Akhtar |
| author_facet | Saniyah Ali Nausheen Henna Uzma Aslam Tayabba Rashid Urfa Shafi Naveed Akhtar |
| author_sort | Saniyah Ali |
| collection | DOAJ |
| description | <p><strong>Background and Objecive: </strong>Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a convenient, less invasive and better diagnostic tool. This study was carried out to determine the diagnostic accuracy of fine-needle aspiration cytology in comparison with cell block from the aspirates taken from focal liver masses.</p>
<p><strong>Methods: </strong>This cross-sectional study was carried out over 13 months inthe Department of Pathology, Allama Iqbal Medical College Lahore, Pakistan in collaboration with the Department of Radiology, Jinnah Hospital Lahore, Pakistan. A total of 60 ultrasound-guided fine-needle aspiration cytological smears along with cell block material were collected from patients with focal liver lesions.Features of malignancy were noted on the fine-needle aspiration of liver lesions followed by cell blocks.</p>
<p><strong>Results: </strong>Cytological diagnosis based on FNAC in 59 cases was benign, out of which 39 (66.0%) were amoebic liver abscess, 14 (23.7%) were pyogenic liver abscess, 2 (3.4%) were tuberculous hepatic abscess supported by the same findings on cell block. One case (1.7%) was diagnosed as malignant on FNAC, later on, confirmed by the cell block. Four (6.7%) cases on FNAC were reported as benign lesions which were later on diagnosed as hepatocellular carcinoma on the cell block. Taking cell block as gold standard, the sensitivity, specificity, positive predictive value negative predictive value and diagnostic accuracy of FNAC was 93%, 100%, 100%, 20% and 93.3% respectively.</p>
<p><strong>Conclusion: </strong>Accurately sampled FNA smears supplemented by cell-block preparation considerably improve the false positive or negative diagnosis.</p> |
| first_indexed | 2024-03-11T10:53:22Z |
| format | Article |
| id | doaj.art-9c68cb4ec43843bcaafc5bdbf37bc4e1 |
| institution | Directory Open Access Journal |
| issn | 2710-3471 |
| language | English |
| last_indexed | 2024-03-11T10:53:22Z |
| publishDate | 2021-03-01 |
| publisher | Discover STM Publishing Ltd |
| record_format | Article |
| series | BioMedica |
| spelling | doaj.art-9c68cb4ec43843bcaafc5bdbf37bc4e12023-11-13T14:11:07ZengDiscover STM Publishing LtdBioMedica2710-34712021-03-01371242810.51441/BioMedica/5-166Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell BlockSaniyah Ali0Nausheen Henna1Uzma Aslam2Tayabba Rashid3Urfa Shafi4Naveed Akhtar5Department of Pathology Shalamar Medical & Dental college, Lahore, Pakistan.Ras Al Khamiah Medical & Health Sciences University, UAEAssistant Professor of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.Demonstrator, Department of Pathology Shalamar Medical & Dental College, Lahore, Pakistan.Associate Professor Pathology Shalamar Medical & Dental College, Lahore, Pakistan.Associate Professor of Rai Medical College, Sargodha, Pakistan.<p><strong>Background and Objecive: </strong>Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a convenient, less invasive and better diagnostic tool. This study was carried out to determine the diagnostic accuracy of fine-needle aspiration cytology in comparison with cell block from the aspirates taken from focal liver masses.</p> <p><strong>Methods: </strong>This cross-sectional study was carried out over 13 months inthe Department of Pathology, Allama Iqbal Medical College Lahore, Pakistan in collaboration with the Department of Radiology, Jinnah Hospital Lahore, Pakistan. A total of 60 ultrasound-guided fine-needle aspiration cytological smears along with cell block material were collected from patients with focal liver lesions.Features of malignancy were noted on the fine-needle aspiration of liver lesions followed by cell blocks.</p> <p><strong>Results: </strong>Cytological diagnosis based on FNAC in 59 cases was benign, out of which 39 (66.0%) were amoebic liver abscess, 14 (23.7%) were pyogenic liver abscess, 2 (3.4%) were tuberculous hepatic abscess supported by the same findings on cell block. One case (1.7%) was diagnosed as malignant on FNAC, later on, confirmed by the cell block. Four (6.7%) cases on FNAC were reported as benign lesions which were later on diagnosed as hepatocellular carcinoma on the cell block. Taking cell block as gold standard, the sensitivity, specificity, positive predictive value negative predictive value and diagnostic accuracy of FNAC was 93%, 100%, 100%, 20% and 93.3% respectively.</p> <p><strong>Conclusion: </strong>Accurately sampled FNA smears supplemented by cell-block preparation considerably improve the false positive or negative diagnosis.</p>https://biomedicapk.com/10.51441/BioMedica/5-166 |
| spellingShingle | Saniyah Ali Nausheen Henna Uzma Aslam Tayabba Rashid Urfa Shafi Naveed Akhtar Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block BioMedica |
| title | Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block |
| title_full | Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block |
| title_fullStr | Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block |
| title_full_unstemmed | Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block |
| title_short | Detection of Malignant Cases From Focal Liver Masses by Fine Needle Aspiration Cytology and Cell Block |
| title_sort | detection of malignant cases from focal liver masses by fine needle aspiration cytology and cell block |
| url | https://biomedicapk.com/10.51441/BioMedica/5-166 |
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