Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman
In the reproductive age group among all ovarian germ cell tumors mature cystic teratoma (MCT) is the most common one. Rarely there is malignant transformation (MT) of MCT with an incidence of 1-3 %. The MT of MCT is mostly in the postmenopausal age group. It is extremely rare in women less than 40 y...
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2023-02-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/09382.pdf |
| _version_ | 1797901459355860992 |
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| author | Subhransu Kumar Hota Nikhil Sharma Pranati Mishra Ranjana Giri Kanak Lata Das Urmila Senapati |
| author_facet | Subhransu Kumar Hota Nikhil Sharma Pranati Mishra Ranjana Giri Kanak Lata Das Urmila Senapati |
| author_sort | Subhransu Kumar Hota |
| collection | DOAJ |
| description | In the reproductive age group among all ovarian germ cell tumors mature cystic teratoma (MCT) is the most common one. Rarely there is malignant transformation (MT) of MCT with an incidence of 1-3 %. The MT of MCT is mostly in the postmenopausal age group. It is extremely rare in women less than 40 years of age. Here we report a case of 35- year old young female who presented with lower abdominal mass and pain abdomen for the last 4 months radiating to back and left thigh. In ultrasonography there was suspicion of left adnexal mass. Contrast enhanced CT scan (CECT) revealed left adnexal mass possibly malignant transformation of teratoma. All the tumor markers were within normal limits except CA19-9 which was elevated (80U/ml). Extensive surgery was done and samples of hysterectomy, bilateral salpingo-oophorectomy, omentectomy along pelvic and paraaortic lymph nodes were sent for histopathology. Histopathology correlated with radiology and revealed extensive areas of necrosis, the predominant component of squamous cell carcinomatous component along with focal areas showing footprints of benign MCT in the form of clusters of fat cells, few hair shafts intermingled with malignant cells. So the final diagnosis of malignant transformation of mature cystic teratoma in form of squamous cell carcinoma was made. The patient was followed up and was showing partial response to ongoing chemotherapy. |
| first_indexed | 2024-04-10T09:02:25Z |
| format | Article |
| id | doaj.art-9c69c57e757545ae9afc5d247e040a26 |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-04-10T09:02:25Z |
| publishDate | 2023-02-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-9c69c57e757545ae9afc5d247e040a262023-02-21T11:02:37ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422023-02-019238238410.21276/obgyn.2023.9.2.37Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive womanSubhransu Kumar Hota 0Nikhil Sharma 1Pranati Mishra2Ranjana Giri 3Kanak Lata Das 4Urmila Senapati5Assistant Professor, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaP.G cum Tutor, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaAssociate Professor, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaProfessor, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaProfessor, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaProfessor & H.O.D, Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, IndiaIn the reproductive age group among all ovarian germ cell tumors mature cystic teratoma (MCT) is the most common one. Rarely there is malignant transformation (MT) of MCT with an incidence of 1-3 %. The MT of MCT is mostly in the postmenopausal age group. It is extremely rare in women less than 40 years of age. Here we report a case of 35- year old young female who presented with lower abdominal mass and pain abdomen for the last 4 months radiating to back and left thigh. In ultrasonography there was suspicion of left adnexal mass. Contrast enhanced CT scan (CECT) revealed left adnexal mass possibly malignant transformation of teratoma. All the tumor markers were within normal limits except CA19-9 which was elevated (80U/ml). Extensive surgery was done and samples of hysterectomy, bilateral salpingo-oophorectomy, omentectomy along pelvic and paraaortic lymph nodes were sent for histopathology. Histopathology correlated with radiology and revealed extensive areas of necrosis, the predominant component of squamous cell carcinomatous component along with focal areas showing footprints of benign MCT in the form of clusters of fat cells, few hair shafts intermingled with malignant cells. So the final diagnosis of malignant transformation of mature cystic teratoma in form of squamous cell carcinoma was made. The patient was followed up and was showing partial response to ongoing chemotherapy.https://journal.barpetaogs.co.in/pdf/09382.pdfdermoid cystyoungsquamous cell carcinomaca-19-9cecthistopathology |
| spellingShingle | Subhransu Kumar Hota Nikhil Sharma Pranati Mishra Ranjana Giri Kanak Lata Das Urmila Senapati Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman New Indian Journal of OBGYN dermoid cyst young squamous cell carcinoma ca-19-9 cect histopathology |
| title | Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman |
| title_full | Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman |
| title_fullStr | Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman |
| title_full_unstemmed | Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman |
| title_short | Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman |
| title_sort | malignant transformation of mature cystic teratoma an enigmatic finding in a reproductive woman |
| topic | dermoid cyst young squamous cell carcinoma ca-19-9 cect histopathology |
| url | https://journal.barpetaogs.co.in/pdf/09382.pdf |
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