Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
<p>Abstract</p> <p>Background</p> <p>Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be du...
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| Format: | Article |
| Language: | English |
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Mattioli 1885
2013-02-01
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| Series: | Multidisciplinary Respiratory Medicine |
| Subjects: | |
| Online Access: | http://www.mrmjournal.com/content/8/1/11 |
| _version_ | 1827266443018764288 |
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| author | Khan Mohammad Afzal |
| author_facet | Khan Mohammad Afzal |
| author_sort | Khan Mohammad Afzal |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-regulation of inflammatory mediators in the airway. It is now well recognized that chronic inflammation as well as airway hyper-responsiveness and remodeling of airway during inflammation, are crucial to asthma. Airway hyper-responsiveness is caused by increased cell proliferation or by hypertrophy of airway smooth muscle cell depending on the nature of the inflammatory stimulation. Airway smooth muscle cell proliferation in asthma is regulated by the proinflammatory cytokines including IL-1β and TNF-α. These proinflammatory cytokines have been shown to influence human airway smooth muscle cell proliferation <it>in vitro,</it> which is due to cyclooxygenase-2 expression, production of prostaglandin E2, and increased cAMP levels.</p> <p>Conclusions</p> <p>This review highlights the role of different proinflammatory cytokines in regulating airway smooth muscle cell growth and also focuses on regulation of differential gene expression in airway smooth muscle cell by growth factors and cytokines, also to bestow unique insight into the effects of conventional asthma therapies on airway smooth muscle cell proliferation and development of new therapeutic strategies to control asthma.</p> |
| first_indexed | 2024-03-07T17:56:59Z |
| format | Article |
| id | doaj.art-9c6a80d6489c4a8490cc4b8e56281a79 |
| institution | Directory Open Access Journal |
| issn | 2049-6958 |
| language | English |
| last_indexed | 2025-03-22T04:17:55Z |
| publishDate | 2013-02-01 |
| publisher | Mattioli 1885 |
| record_format | Article |
| series | Multidisciplinary Respiratory Medicine |
| spelling | doaj.art-9c6a80d6489c4a8490cc4b8e56281a792024-04-28T08:04:14ZengMattioli 1885Multidisciplinary Respiratory Medicine2049-69582013-02-01811110.1186/2049-6958-8-11Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesisKhan Mohammad Afzal<p>Abstract</p> <p>Background</p> <p>Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-regulation of inflammatory mediators in the airway. It is now well recognized that chronic inflammation as well as airway hyper-responsiveness and remodeling of airway during inflammation, are crucial to asthma. Airway hyper-responsiveness is caused by increased cell proliferation or by hypertrophy of airway smooth muscle cell depending on the nature of the inflammatory stimulation. Airway smooth muscle cell proliferation in asthma is regulated by the proinflammatory cytokines including IL-1β and TNF-α. These proinflammatory cytokines have been shown to influence human airway smooth muscle cell proliferation <it>in vitro,</it> which is due to cyclooxygenase-2 expression, production of prostaglandin E2, and increased cAMP levels.</p> <p>Conclusions</p> <p>This review highlights the role of different proinflammatory cytokines in regulating airway smooth muscle cell growth and also focuses on regulation of differential gene expression in airway smooth muscle cell by growth factors and cytokines, also to bestow unique insight into the effects of conventional asthma therapies on airway smooth muscle cell proliferation and development of new therapeutic strategies to control asthma.</p>http://www.mrmjournal.com/content/8/1/11Airway inflammationAirway smooth muscle cellsAsthma |
| spellingShingle | Khan Mohammad Afzal Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis Multidisciplinary Respiratory Medicine Airway inflammation Airway smooth muscle cells Asthma |
| title | Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| title_full | Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| title_fullStr | Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| title_full_unstemmed | Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| title_short | Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| title_sort | inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis |
| topic | Airway inflammation Airway smooth muscle cells Asthma |
| url | http://www.mrmjournal.com/content/8/1/11 |
| work_keys_str_mv | AT khanmohammadafzal inflammationsignalsairwaysmoothmusclecellproliferationinasthmapathogenesis |