Impulsive choice predicts poor working memory in male rats.
A number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the sa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3986066?pdf=render |
| _version_ | 1818683774900109312 |
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| author | C Renee Renda Jeffrey S Stein Gregory J Madden |
| author_facet | C Renee Renda Jeffrey S Stein Gregory J Madden |
| author_sort | C Renee Renda |
| collection | DOAJ |
| description | A number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the same maladaptive behaviors. Human studies suggest that impulsive choice is associated with working memory ability but, to date, only one study has explored the association between working memory and impulsive choice in rats and no relation was reported. The current study reevaluated the association between working memory and impulsive choice in 19 male Long-Evans rats. Psychophysical adjusting procedures were used to quantify working memory (titrating-delay match-to-position procedure) and impulsive choice (adjusting delay procedure). Rats were partitioned into low- and high-impulsive groups based on performance in the impulsive choice task. Low-impulsive rats performed significantly better in the working memory assessment. Across all rats, impulsive choice was negatively correlated with working memory performance. These findings support the hypothesis that prefrontal cortex function, specifically, working memory, is related to impulsive choice. Future research might profitably examine the experimental variables designed to influence working memory to evaluate the effects of these variables on impulsive choice and maladaptive behaviors with which it is correlated. |
| first_indexed | 2024-12-17T10:40:05Z |
| format | Article |
| id | doaj.art-9c6b3a5018d04bf296c5015348d3a8b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T10:40:05Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9c6b3a5018d04bf296c5015348d3a8b12022-12-21T21:52:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9326310.1371/journal.pone.0093263Impulsive choice predicts poor working memory in male rats.C Renee RendaJeffrey S SteinGregory J MaddenA number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the same maladaptive behaviors. Human studies suggest that impulsive choice is associated with working memory ability but, to date, only one study has explored the association between working memory and impulsive choice in rats and no relation was reported. The current study reevaluated the association between working memory and impulsive choice in 19 male Long-Evans rats. Psychophysical adjusting procedures were used to quantify working memory (titrating-delay match-to-position procedure) and impulsive choice (adjusting delay procedure). Rats were partitioned into low- and high-impulsive groups based on performance in the impulsive choice task. Low-impulsive rats performed significantly better in the working memory assessment. Across all rats, impulsive choice was negatively correlated with working memory performance. These findings support the hypothesis that prefrontal cortex function, specifically, working memory, is related to impulsive choice. Future research might profitably examine the experimental variables designed to influence working memory to evaluate the effects of these variables on impulsive choice and maladaptive behaviors with which it is correlated.http://europepmc.org/articles/PMC3986066?pdf=render |
| spellingShingle | C Renee Renda Jeffrey S Stein Gregory J Madden Impulsive choice predicts poor working memory in male rats. PLoS ONE |
| title | Impulsive choice predicts poor working memory in male rats. |
| title_full | Impulsive choice predicts poor working memory in male rats. |
| title_fullStr | Impulsive choice predicts poor working memory in male rats. |
| title_full_unstemmed | Impulsive choice predicts poor working memory in male rats. |
| title_short | Impulsive choice predicts poor working memory in male rats. |
| title_sort | impulsive choice predicts poor working memory in male rats |
| url | http://europepmc.org/articles/PMC3986066?pdf=render |
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