The History of Pertussis Toxin
Besides the typical whooping cough syndrome, infection with <i>Bordetella pertussis</i> or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection aga...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/9/623 |
| _version_ | 1827681191978860544 |
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| author | Camille Locht Rudy Antoine |
| author_facet | Camille Locht Rudy Antoine |
| author_sort | Camille Locht |
| collection | DOAJ |
| description | Besides the typical whooping cough syndrome, infection with <i>Bordetella pertussis</i> or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initially believed to be associated with different molecular entities, decades of research have provided the demonstration that these activities are all due to a single molecule today referred to as pertussis toxin. The three-dimensional structure and molecular mechanisms of pertussis toxin action, as well as its role in protective immunity have been uncovered in the last 50 years. In this article, we review the history of pertussis toxin, including the paradigm shift that occurred in the 1980s which established the pertussis toxin as a single molecule. We describe the role molecular biology played in the understanding of pertussis toxin action, its role as a molecular tool in cell biology and as a protective antigen in acellular pertussis vaccines and possibly new-generation vaccines, as well as potential therapeutical applications. |
| first_indexed | 2024-03-10T07:09:49Z |
| format | Article |
| id | doaj.art-9c6b92190ee34cb6af83fac60ddc61f4 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T07:09:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-9c6b92190ee34cb6af83fac60ddc61f42023-11-22T15:31:06ZengMDPI AGToxins2072-66512021-09-0113962310.3390/toxins13090623The History of Pertussis ToxinCamille Locht0Rudy Antoine1Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, FranceBesides the typical whooping cough syndrome, infection with <i>Bordetella pertussis</i> or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initially believed to be associated with different molecular entities, decades of research have provided the demonstration that these activities are all due to a single molecule today referred to as pertussis toxin. The three-dimensional structure and molecular mechanisms of pertussis toxin action, as well as its role in protective immunity have been uncovered in the last 50 years. In this article, we review the history of pertussis toxin, including the paradigm shift that occurred in the 1980s which established the pertussis toxin as a single molecule. We describe the role molecular biology played in the understanding of pertussis toxin action, its role as a molecular tool in cell biology and as a protective antigen in acellular pertussis vaccines and possibly new-generation vaccines, as well as potential therapeutical applications.https://www.mdpi.com/2072-6651/13/9/623ADP-ribosylationleukocytosishistamine sensitizationislet activationG proteinspertussis vaccines |
| spellingShingle | Camille Locht Rudy Antoine The History of Pertussis Toxin Toxins ADP-ribosylation leukocytosis histamine sensitization islet activation G proteins pertussis vaccines |
| title | The History of Pertussis Toxin |
| title_full | The History of Pertussis Toxin |
| title_fullStr | The History of Pertussis Toxin |
| title_full_unstemmed | The History of Pertussis Toxin |
| title_short | The History of Pertussis Toxin |
| title_sort | history of pertussis toxin |
| topic | ADP-ribosylation leukocytosis histamine sensitization islet activation G proteins pertussis vaccines |
| url | https://www.mdpi.com/2072-6651/13/9/623 |
| work_keys_str_mv | AT camillelocht thehistoryofpertussistoxin AT rudyantoine thehistoryofpertussistoxin AT camillelocht historyofpertussistoxin AT rudyantoine historyofpertussistoxin |