Autophagy-Related Gene WD Repeat Domain 45B Promotes Tumor Proliferation and Migration of Hepatocellular Carcinoma through the Akt/mTOR Signaling Pathway
Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor. It has been found that autophagy plays a role both as a tumor promoter and inhibitor in HCC carcinogenesis. However, the mechanism behind is still unveiled. This study aims to explore the functions and mechanism of the key autoph...
Main Authors: | Jiahao Li, Lansi Chen, Jingjing Pang, Chunxiu Yang, Wen Xie, Guoyan Shen, Hongshan Chen, Xiaoyi Li, Shu-Yuan Xiao, Yueying Li |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/13/5/906 |
Similar Items
-
Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
by: Lijun Lv, et al.
Published: (2023-03-01) -
Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials
by: Choudhary Harsha, et al.
Published: (2020-05-01) -
Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
by: Jong Hyun Lee, et al.
Published: (2019-02-01) -
Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro
by: Ching-Yeh Lin, et al.
Published: (2023-02-01) -
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway
by: Yuheng Jiao, et al.
Published: (2022-02-01)