Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated lung aging. Over the past two decades, mounting evidence suggests an accumulation of senescent cells within the lungs of patients with COPD that contributes to dysregulated tissue repair and the secretion of multi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/6/817 |
| _version_ | 1827658611608780800 |
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| author | Melissa Rivas Gayatri Gupta Louis Costanzo Huma Ahmed Anne E. Wyman Patrick Geraghty |
| author_facet | Melissa Rivas Gayatri Gupta Louis Costanzo Huma Ahmed Anne E. Wyman Patrick Geraghty |
| author_sort | Melissa Rivas |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated lung aging. Over the past two decades, mounting evidence suggests an accumulation of senescent cells within the lungs of patients with COPD that contributes to dysregulated tissue repair and the secretion of multiple inflammatory proteins, termed the senescence-associated secretory phenotype (SASP). Cellular senescence in COPD is linked to telomere dysfunction, DNA damage, and oxidative stress. This review gives an overview of the mechanistic contributions and pathologic consequences of cellular senescence in COPD and discusses potential therapeutic approaches targeting senescence-associated signaling in COPD. |
| first_indexed | 2024-03-09T23:06:04Z |
| format | Article |
| id | doaj.art-9c6cbb11faaf4f2692adb69239a53a5d |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:06:04Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-9c6cbb11faaf4f2692adb69239a53a5d2023-11-23T17:53:05ZengMDPI AGMedicina1010-660X1648-91442022-06-0158681710.3390/medicina58060817Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary DiseaseMelissa Rivas0Gayatri Gupta1Louis Costanzo2Huma Ahmed3Anne E. Wyman4Patrick Geraghty5Department of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USASection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USAChronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated lung aging. Over the past two decades, mounting evidence suggests an accumulation of senescent cells within the lungs of patients with COPD that contributes to dysregulated tissue repair and the secretion of multiple inflammatory proteins, termed the senescence-associated secretory phenotype (SASP). Cellular senescence in COPD is linked to telomere dysfunction, DNA damage, and oxidative stress. This review gives an overview of the mechanistic contributions and pathologic consequences of cellular senescence in COPD and discusses potential therapeutic approaches targeting senescence-associated signaling in COPD.https://www.mdpi.com/1648-9144/58/6/817chronic obstructive pulmonary diseasesenescencecigarette smokeaging |
| spellingShingle | Melissa Rivas Gayatri Gupta Louis Costanzo Huma Ahmed Anne E. Wyman Patrick Geraghty Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease Medicina chronic obstructive pulmonary disease senescence cigarette smoke aging |
| title | Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease |
| title_full | Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease |
| title_short | Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease |
| title_sort | senescence pathogenic driver in chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease senescence cigarette smoke aging |
| url | https://www.mdpi.com/1648-9144/58/6/817 |
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